发明公开
EP2454268A1 2,3-FLUORINATED GLYCOSIDES AS NEURAMINIDASE INHIBITORS AND THEIR USE AS ANTI-VIRALS
有权
2,3-FLUORINIER GLYCOSIDE ALS NEURAMINIDASE-HEMMER UND IHRE VERWENDUNG ALS ANTIVIRUSMITTEL
- 专利标题： 2,3-FLUORINATED GLYCOSIDES AS NEURAMINIDASE INHIBITORS AND THEIR USE AS ANTI-VIRALS
- 专利标题（中）： 2,3-FLUORINIER GLYCOSIDE ALS NEURAMINIDASE-HEMMER UND IHRE VERWENDUNG ALS ANTIVIRUSMITTEL
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申请号： EP10799312.3申请日： 2010-07-15
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公开(公告)号： EP2454268A1公开(公告)日： 2012-05-23
- 发明人: WITHERS, Stephen , WATTS, Andrew Graham , KIM, Jin Hyo , WENNEKES, Tom
- 申请人： The University of British Columbia
- 申请人地址： University - Industry Liaison Office 103 - 6190 Agronomy Road Vancouver, BC V6T 1Z3 CA
- 专利权人： The University of British Columbia
- 当前专利权人： The University of British Columbia
- 当前专利权人地址： University - Industry Liaison Office 103 - 6190 Agronomy Road Vancouver, BC V6T 1Z3 CA
- 代理机构： Lundquist, Tomas
- 优先权： US213786P 20090715
- 国际公布： WO2011006237 20110120
- 主分类号： C07H5/02
- IPC分类号： C07H5/02 ; A61K31/7012 ; A61P31/16 ; C07H13/04 ; C07H13/12 ; C07H15/12 ; C07H15/18 ; C12N9/24
摘要：
Compounds of structural formula (I) useful for the treatment or prophylaxis of viral infection, particularly viral influenza are provided Pharmaceutical preparations thereof and methods for their preparation are also described. The therapeutic effect is achieved via inhibition of viral neuraminidases, also known as viral sialidases. These neuraminidases are classified under the GH34 family of viral enzymes.
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