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1.发明授权2,3-FLUORINATED GLYCOSIDES AS NEURAMINIDASE INHIBITORS AND THEIR USE AS ANTI-VIRALS 有权2,3-糖苷氟化ALS神经氨酸酶抑制剂和它们作为抗病毒剂
公开(公告)号：EP2454268B1
公开(公告)日：2014-09-10
申请号：EP10799312.3
申请日：2010-07-15
IPC分类号： C07H5/02 , A61K31/7012 , A61P31/16 , C07H13/04 , C07H13/12 , C07H15/12 , C07H15/18 , C12N9/24
CPC分类号： C07D309/14 , A61K31/351 , A61K31/655 , C07H1/00 , C07H13/00 , C07H13/04 , C07H13/12 , C07H15/12 , C07H15/18
摘要： Compounds of structural formula (I) useful for the treatment or prophylaxis of viral infection, particularly viral influenza are provided Pharmaceutical preparations thereof and methods for their preparation are also described. The therapeutic effect is achieved via inhibition of viral neuraminidases, also known as viral sialidases. These neuraminidases are classified under the GH34 family of viral enzymes.
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2.发明公开2,3-FLUORINATED GLYCOSIDES AS NEURAMINIDASE INHIBITORS AND THEIR USE AS ANTI-VIRALS 有权2,3-FLUORINIER GLYCOSIDE ALS NEURAMINIDASE-HEMMER UND IHRE VERWENDUNG ALS ANTIVIRUSMITTEL
公开(公告)号：EP2454268A1
公开(公告)日：2012-05-23
申请号：EP10799312.3
申请日：2010-07-15
IPC分类号： C07H5/02 , A61K31/7012 , A61P31/16 , C07H13/04 , C07H13/12 , C07H15/12 , C07H15/18 , C12N9/24
CPC分类号： C07D309/14 , A61K31/351 , A61K31/655 , C07H1/00 , C07H13/00 , C07H13/04 , C07H13/12 , C07H15/12 , C07H15/18
摘要： Compounds of structural formula (I) useful for the treatment or prophylaxis of viral infection, particularly viral influenza are provided Pharmaceutical preparations thereof and methods for their preparation are also described. The therapeutic effect is achieved via inhibition of viral neuraminidases, also known as viral sialidases. These neuraminidases are classified under the GH34 family of viral enzymes.
摘要翻译： 提供可用于治疗或预防病毒感染的结构式（I）的化合物，特别是病毒性流感。还描述了其药物制剂及其制备方法。 治疗效果通过抑制病毒性神经氨酸酶（也称为病毒性唾液酸酶）来实现。 这些神经氨酸酶分类为GH34家族的病毒酶。
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