发明公开
EP2457925A1 Process for preparing a macrocyclic modulator of the ghrelin receptor and intermediates
审中-公开
Verfahren zur Herstellung eines makrozyklischen调制器des Ghrelin-Rezeptors und Zwischenprodukte
- 专利标题： Process for preparing a macrocyclic modulator of the ghrelin receptor and intermediates
- 专利标题（中）： Verfahren zur Herstellung eines makrozyklischen调制器des Ghrelin-Rezeptors und Zwischenprodukte
-
申请号： EP11009051.1申请日： 2005-06-13
-
公开(公告)号： EP2457925A1公开(公告)日： 2012-05-30
- 发明人: Hoveyda, Hamid , Peterson, Mark L. , Fraser, Graeme , Ramaseshan, Mahesh
- 申请人： Tranzyme Pharma, Inc.
- 申请人地址： 4819 Emperor Blvd. Suite 400 Durham, NC 27703 US
- 专利权人： Tranzyme Pharma, Inc.
- 当前专利权人： Tranzyme Pharma, Inc.
- 当前专利权人地址： 4819 Emperor Blvd. Suite 400 Durham, NC 27703 US
- 代理机构： McNab, Donald C.
- 优先权： US872142 20040618; US621642P 20041026; US622005P 20041027; US642271P 20050107; US149731 20050610
- 主分类号： C07K5/087
- IPC分类号： C07K5/087 ; C07K5/12
摘要：
The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.
信息查询
