发明公开
EP2465847A1 AZETIDINONE COMPOUNDS AND MEDICAL USE THEREOF
有权
AZETIDINONVERBINDUNGEN UND IHRE MEDISINISCHE VERWENDUNG
- 专利标题： AZETIDINONE COMPOUNDS AND MEDICAL USE THEREOF
- 专利标题（中）： AZETIDINONVERBINDUNGEN UND IHRE MEDISINISCHE VERWENDUNG
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申请号： EP10807852.8申请日： 2010-08-09
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公开(公告)号： EP2465847A1公开(公告)日： 2012-06-20
- 发明人: BAI, Hua , ZHAO, Xuyang , XU, Xiaojie , LIU, Xiaoyu , ZHANG, Yuncai , CHEN, Ying , ZHENG, Xiaohe , GU, Maojian , ZHU, Qifeng , ZHANG, Yong , LUO, Hairong
- 申请人： Zhejiang Hisun Pharmaceutical Co. Ltd.
- 申请人地址： No. 46 Waisha Road Jiaojiang District Taizhou Zhejiang 318000 CN
- 专利权人： Zhejiang Hisun Pharmaceutical Co. Ltd.
- 当前专利权人： Zhejiang Hisun Pharmaceutical Co. Ltd.
- 当前专利权人地址： No. 46 Waisha Road Jiaojiang District Taizhou Zhejiang 318000 CN
- 代理机构： Kehoe, Laura Ellen
- 优先权： CN200910162888 20090811
- 国际公布： WO2011017907 20110217
- 主分类号： C07D205/08
- IPC分类号： C07D205/08 ; C07D263/26 ; A61K31/397 ; A61P3/06 ; A61P9/00 ; A61P9/04 ; A61P9/10
摘要：
Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention.
公开/授权文献
- EP2465847B1 AZETIDINONE COMPOUNDS AND MEDICAL USE THEREOF 公开/授权日：2016-10-12
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