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13 条记录 (耗时 0.021 秒)

    4-((SUBSTITUTED PHENYL) DIFLUOROMETHYL) PHENOXY CARBOXYLIC ACID DERIVATIVE, AND PREPARATION METHOD AND USES THEREOF
    1.
    发明公开
    4-((SUBSTITUTED PHENYL) DIFLUOROMETHYL) PHENOXY CARBOXYLIC ACID DERIVATIVE, AND PREPARATION METHOD AND USES THEREOF 审中-公开
    4 - （（SUBSTITUIERTE PHENYL）DIFLUORMETHYL）酚氧化合物在HERSTELLUNGSVERFAHREN UND VERWENDUNGEN DAVON

    公开(公告)号：EP2842931A1

    公开(公告)日：2015-03-04

    申请号：EP13781382.0

    申请日：2013-04-25

    申请人： Zhejiang Hisun Pharmaceutical Co. Ltd.

    发明人： BAI, Hua ,  HONG, Jian ,  CAI, Lifeng ,  WEI, Hegeng ,  LIU, Xiaoyu ,  ZHENG, Xiaohe

    IPC分类号： C07C59/68 ,  C07C51/41 ,  A61K31/192 ,  A61P3/06

    CPC分类号： C07C69/712 ,  C07C51/363 ,  C07C59/135 ,  C07C59/68 ,  C07C67/307 ,  C07C69/78 ,  C07C69/94 ,  C07C319/16 ,  C07C323/16 ,  C07C323/56 ,  C07D307/33

    摘要： Disclosed are a 4-((substituted phenyl) difluoromethyl) phenoxy carboxylic acid derivative, and preparation method and uses thereof. More particularly, the present invention relates to a compound having a structure as represented by formula I and defined in the description. The compound of the present invention can be used as a PPAR agonist, and demonstrates a relatively strong effect on reducing the levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) in plasma. Therefore, the compound of the present invention can be used to prepare drugs for treating or preventing hyperlipemia, or cardiovascular and cerebrovascular diseases caused by hyperlipemia, such as diabetes, atherosclerosis, stoke, and coronary heart disease. The present invention also relates to a novel intermediate compound for preparing the compound as represented by formula I, and preparation method thereof.

    摘要翻译： 公开了4 - （（取代苯基）二氟甲基）苯氧基羧酸衍生物及其制备方法和用途。 更具体地说，本发明涉及具有由式I表示并在说明书中定义的结构的化合物。 本发明化合物可用作PPAR激动剂，并且对降低血浆中总胆固醇（TC），甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）的水平具有较强的作用。 因此，本发明的化合物可用于制备用于治疗或预防高脂血症或由高脂血症引起的心血管和脑血管疾病如糖尿病，动脉粥样硬化，卒中和冠心病的药物。 本发明还涉及一种制备式I表示的化合物的新型中间体化合物及其制备方法。

    AZETIDINONE COMPOUNDS AND MEDICAL USE THEREOF
    7.
    发明公开
    AZETIDINONE COMPOUNDS AND MEDICAL USE THEREOF 有权
    AZETIDINONVERBINDUNGEN UND IHRE MEDISINISCHE VERWENDUNG

    公开(公告)号：EP2465847A1

    公开(公告)日：2012-06-20

    申请号：EP10807852.8

    申请日：2010-08-09

    申请人： Zhejiang Hisun Pharmaceutical Co. Ltd.

    发明人： BAI, Hua ,  ZHAO, Xuyang ,  XU, Xiaojie ,  LIU, Xiaoyu ,  ZHANG, Yuncai ,  CHEN, Ying ,  ZHENG, Xiaohe ,  GU, Maojian ,  ZHU, Qifeng ,  ZHANG, Yong ,  LUO, Hairong

    IPC分类号： C07D205/08 ,  C07D263/26 ,  A61K31/397 ,  A61P3/06 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10

    CPC分类号： A61K31/397 ,  C07D205/08 ,  C07D263/26

    摘要： Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention.

    摘要翻译： 氮杂环丁酮化合物的制备及其医疗用途由本发明提供。 更具体地说，式（I）所示的氮杂环丁烷化合物，其中R 1，R 2，R 3，R 4，R 5和R 6在说明书中定义，其制备方法由本发明提供。 本发明的化合物可以降低血浆中总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）的水平，可用作降低血液中胆固醇的药物。 因此，本发明的化合物可用于治疗或预防动脉粥样硬化，血管紧张素，心力衰竭，冠状动脉疾病，心血管病，心肌，心绞痛，高脂血症和高胆固醇血症等疾病。 式（I）化合物和中间体化合物的制备方法也由本发明提供。