发明公开
EP2467368A1 3-AMINO-5-PHENYL-5,6-DIHYDRO-2H-[1,4]OXAZINE DERIVATIVES
审中-公开
3-氨基-5-苯基-5,6-二氢-2H- [1,4]恶嗪衍生物
- 专利标题： 3-AMINO-5-PHENYL-5,6-DIHYDRO-2H-[1,4]OXAZINE DERIVATIVES
- 专利标题（中）： 3-氨基-5-苯基-5,6-二氢-2H- [1,4]恶嗪衍生物
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申请号： EP10742166.1申请日： 2010-08-16
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公开(公告)号： EP2467368A1公开(公告)日： 2012-06-27
- 发明人: ANDREINI, Matteo , BANNER, David , GUBA, Wolfgang , HILPERT, Hans , MAUSER, Harald , MAYWEG, Alexander, V. , NARQUIZIAN, Robert , POWER, Eoin , ROGERS-EVANS, Mark , TRAVAGLI, Massimiliano , VALACCHI, Michela , WOLTERING, Thomas , WOSTL, Wolfgang , GABALLIERI, Emanuele
- 申请人： F.Hoffmann-La Roche AG , Siena Biotech S.p.a.
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F.Hoffmann-La Roche AG,Siena Biotech S.p.a.
- 当前专利权人： F.Hoffmann-La Roche AG,Siena Biotech S.p.a.
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Müller-Afraz, Simona
- 优先权： EP09168132 20090819
- 国际公布： WO2011020806 20110224
- 主分类号： C07D265/30
- IPC分类号： C07D265/30 ; C07D413/12 ; A61K31/5377
摘要：
The present invention relates to 3-Amino-5-phenyl-5,6-dihydro-2H-[l,4]oxazine derivatives of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
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