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公开(公告)号：EP2603496A1
公开(公告)日：2013-06-19
申请号：EP11739092.2
申请日：2011-08-05
发明人： BANNER, David , GABELLIERI, Emanuele , GUBA, Wolfgang , HILPERT, Hans , HORNSPERGER, Benoit , HUMM, Roland , MAUSER, Harald , MAYWEG, Alexander, V. , NARQUIZIAN, Robert , PINARD, Emmanuel , ROGERS-EVANS, Mark , WOLTERING, Thomas , WOSTL, Wolfgang
IPC分类号： C07D239/22 , C07D239/70 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/513 , A61P3/10
CPC分类号： C07D417/12 , A61K31/513 , C07D239/22 , C07D239/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： This invention relates to compounds of the formula wherein R
1 to R
9 are as described below, or to pharmaceutically acceptable salts thereof. These compounds are BACE2 inhibitors and can be used as medicaments for the therapeutic and/or prophylactic treatment of diseases such as diabetes, particularly type 2 diabetes, and other metabolic disorders.摘要翻译： 本发明涉及下式的化合物或其可药用盐，其中R 1至R 9如下所述。 这些化合物是BACE2抑制剂，并且可以用作治疗和/或预防性治疗诸如糖尿病，特别是2型糖尿病和其他代谢疾病的疾病的药物。
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2.发明授权2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS 有权2,5,6,7-四氢 - [1,4]氧杂环己烯-3-基亚胺ODER 2,3,6,7-四氢 - [1,4]氧杂环己烯-5-木兰VERBINDUNGEN
公开(公告)号：EP2566855B1
公开(公告)日：2014-05-21
申请号：EP11720065.9
申请日：2011-05-03
发明人： BANNER, David , GUBA, Wolfgang , HILPERT, Hans , HUMM, Roland , MAUSER, Harald , MAYWEG, Alexander, V. , NARQUIZIAN, Robert , POWER, Eoin , ROGERS-EVANS, Mark , ROMBACH, Didier , WOLTERING, Thomas , WOSTL, Wolfgang
IPC分类号： C07D267/10 , C07D413/12 , C07D417/12 , A61K31/553 , A61P25/28
CPC分类号： C07D267/10 , C07D413/12 , C07D417/12
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3.发明公开
公开(公告)号：EP2718286A1
公开(公告)日：2014-04-16
申请号：EP12725743.4
申请日：2012-06-04
发明人： WOLTERING, Thomas
IPC分类号： C07D413/12 , A61K31/5355 , A61P25/28
CPC分类号： C07D413/12
摘要： The present invention provides compounds of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
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公开(公告)号：EP2709992A1
公开(公告)日：2014-03-26
申请号：EP12722112.5
申请日：2012-05-11
发明人： HILPERT, Hans , NARQUIZIAN, Robert , PINARD, Emmanuel , POLARA, Alessandra , ROGERS-EVANS, Mark , WOLTERING, Thomas , WOSTL, Wolfgang
IPC分类号： C07D265/08 , C07D413/10 , C07D413/12 , A61K31/5355 , A61K31/535 , A61P25/28
CPC分类号： C07D413/10 , C07D265/08 , C07D413/12
摘要： The present invention provides compounds of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译： 本发明提供了具有BACE1和/或BACE2抑制活性的式I化合物，它们的制造方法，含有它们的药物组合物以及它们作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默病和2型糖尿病。
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公开(公告)号：EP2984086A1
公开(公告)日：2016-02-17
申请号：EP14715908.1
申请日：2014-04-08
发明人： HILPERT, Hans , HUMM, Roland , MUSER, Thorsten , SCHNIDER, Christian , WERMUTH, Roger , WOLTERING, Thomas
IPC分类号： C07D413/14 , A61K31/5355 , A61P25/28 , A61P35/00 , A61P29/00
CPC分类号： C07D413/14
摘要： The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：EP2807155A1
公开(公告)日：2014-12-03
申请号：EP13701072.4
申请日：2013-01-23
发明人： HILPERT, Hans , HUMM, Roland , WOLTERING, Thomas
IPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , A61K31/535 , A61K31/5355
CPC分类号： C07D413/12 , C07D401/12 , C07D403/12
摘要： The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：EP2694495A1
公开(公告)日：2014-02-12
申请号：EP12713127.4
申请日：2012-04-02
IPC分类号： C07D413/10 , C07D417/10 , A61K31/553 , A61P3/10 , A61P25/28
CPC分类号： C07D413/10 , C07D267/10 , C07D413/14 , C07D417/10
摘要： The present invention relates to 1,4 Oxazepines of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译： 本发明涉及具有BACE1和/或BACE2抑制活性的式（I）的1,4氧杂吖庚因，它们的制造方法，含有它们的药物组合物以及它们作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默病和2型糖尿病。
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8.发明公开2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS 有权-2,5,6,7-四氢 - [1,4]氧氮杂-3-基胺OR -2,3,6,7-四氢 - [1,4]氧氮杂-5-基胺化合物
公开(公告)号：EP2566855A1
公开(公告)日：2013-03-13
申请号：EP11720065.9
申请日：2011-05-03
发明人： BANNER, David , GUBA, Wolfgang , HILPERT, Hans , HUMM, Roland , MAUSER, Harald , MAYWEG, Alexander, V. , NARQUIZIAN, Robert , POWER, Eoin , ROGERS-EVANS, Mark , ROMBACH, Didier , WOLTERING, Thomas , WOSTL, Wolfgang
IPC分类号： C07D267/10 , C07D413/12 , C07D417/12 , A61K31/553 , A61P25/28
CPC分类号： C07D267/10 , C07D413/12 , C07D417/12
摘要： This invention relates to compounds of the formula (I), wherein A, B and R
1 to R
7 are as described below, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as 5 medicaments for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.-
公开(公告)号：EP2948446A1
公开(公告)日：2015-12-02
申请号：EP14700493.1
申请日：2014-01-15
发明人： WOLTERING, Thomas , GUBA, Wolfgang , HILPERT, Hans , KUGLSTATTER, Andreas , LIMBERG, Anja , OBST SANDER, Ulrike , PINARD, Emmanuel , WOSTL, Wolfgang
IPC分类号： C07D413/14 , C07D413/10 , C07D413/12 , A61K31/5355 , A61P25/28
CPC分类号： C07D413/14 , C07D413/04 , C07D413/10 , C07D413/12
摘要： The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
摘要翻译： 本发明提供具有BACE1抑制活性的式I化合物，其制备方法，含有它们的药物组合物及其作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默氏病。
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公开(公告)号：EP2686307A1
公开(公告)日：2014-01-22
申请号：EP12709616.2
申请日：2012-03-15
发明人： GABELLIERI, Emanuele , GUBA, Wolfgang , HILPERT, Hans , MAUSER, Harald , MAYWEG, Alexander V. , ROGERS-EVANS, Mark , ROMBACH, Didier , THOMAS, Andrew , WOLTERING, Thomas , WOSTL, Wolfgang
IPC分类号： C07D267/10 , C07D413/12 , A61K31/553 , A61P25/28 , A61P3/10
CPC分类号： C07D267/10 , C07D413/12
摘要： The present invention relates to 1,4-Oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
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