发明公开
EP2470657A2 TREATMENT OF 'IQ MOTIF CONTAINING GTPASE ACTIVATING PROTEIN' (IQGAP) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IQGAP
审中-公开
IQGAP（“IQ MOTIF含酶激活蛋白”）的治疗 - 相关疾病BY抑制天然反义转录反对IQGAP的
- 专利标题： TREATMENT OF 'IQ MOTIF CONTAINING GTPASE ACTIVATING PROTEIN' (IQGAP) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IQGAP
- 专利标题（中）： IQGAP（“IQ MOTIF含酶激活蛋白”）的治疗 - 相关疾病BY抑制天然反义转录反对IQGAP的
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申请号： EP10815846.0申请日： 2010-08-25
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公开(公告)号： EP2470657A2公开(公告)日： 2012-07-04
- 发明人: COLLARD, Joseph , KHORKOVA SHERMAN, Olga , COITO, Carlos
- 申请人： Opko Curna, LLC
- 申请人地址： 4400 Biscayne Boulevard Miami, FL 33137 US
- 专利权人： Opko Curna, LLC
- 当前专利权人： Opko Curna, LLC
- 当前专利权人地址： 4400 Biscayne Boulevard Miami, FL 33137 US
- 代理机构： Evenson, Jane Harriet
- 优先权： US236727P 20090825
- 国际公布： WO2011031482 20110317
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K48/00 ; A61K31/7088 ; C12N15/63 ; C12N15/52
摘要：
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of 'IQ motif containing GTPase activating protein' (IQGAP), in particular, by targeting natural antisense polynucleotides of 'IQ motif containing GTPase activating protein' (IQGAP). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IQGAP.
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