公开(公告)号：EP4461819A1

公开(公告)日：2024-11-13

申请号：EP22919080.6

申请日：2022-12-23

申请人： Seegene, Inc.

发明人： KWON, Suk-Tae ,  NA, Hyewon ,  CHO, Sung Suk ,  KWON, Chanho

IPC分类号： C12Q1/6848 ,  C12N9/24 ,  C12N15/52 ,  C12N15/70 ,  C07K1/16

摘要： The present invention relates to uracil-DNA glycosylase (UDG) derived from Photobacterium leiognathi and to the use thereof. The novel UDG of the present invention is an enzyme isolated from Photobacterium leiognathi, which is a psychrophilic bacterium, and is characterized by having an activity of degrading uracil bases from uracil-containing DNA substrate and being easily denatured at low temperatures. Accordingly, the UDG of the present invention can be effectively used to eliminate carryover contamination occurring during the nucleic acid amplification reaction, resulting in increased accuracy (elimination of false positives), purity and amplification efficiency in nucleic acid amplification reactions.

公开(公告)号：EP4397760A3

公开(公告)日：2024-10-09

申请号：EP24165204.9

申请日：2013-10-23

申请人： Toolgen Incorporated

发明人： KIM, Jin-Soo ,  CHO, Seung Woo ,  KIM, Sojung

IPC分类号： C12N15/11 ,  C12N9/22 ,  C12N9/16 ,  C12N15/10 ,  C12N15/52 ,  C12N15/63

CPC分类号： C12N2310/53120130101 ,  C12N15/8216 ,  C12Y301/21 ,  C12N9/22 ,  C12N15/102 ,  C12N15/63 ,  C12N9/16 ,  C12N15/52 ,  C12N15/111 ,  C12N2310/2020170501

摘要： The present invention relates to targeted genome editing in eukaryotic cells or organisms. More particularly, the present invention relates to a composition for cleaving a target DNA in eukaryotic cells or organisms comprising a guide RNA specific for the target DNA and Cas9 protein, and uses thereof.

公开(公告)号：EP4437839A1

公开(公告)日：2024-10-02

申请号：EP24166986.0

申请日：2024-03-27

申请人： Benson Hill, Inc.

发明人： BEGEMANN, Matthew Brett ,  GOETTEL, Herbert Wolfgang ,  FRICK, Elizabeth May ,  ZESS, Erin Kathleen

IPC分类号： A01H6/54 ,  C07H3/06 ,  C12N9/10 ,  C12N15/82 ,  C12N15/52

CPC分类号： C12N9/1051 ,  A01H6/542 ,  A01H6/546 ,  C12N15/8246 ,  C07H3/06 ,  C12N15/52 ,  C12Y204/01123 ,  C12Y204/01082

摘要： Provided herein are plants, plant parts, a population of plants or plant parts, and plant products (e.g., seed composition, protein and/or oil composition) comprising reduced galactinol synthase (GAS) and/or raffinose synthase (RS) activity, and compositions and methods of producing such plants and plant parts. The plants, plant parts, population of plants or plant parts, or plant products can have a genetic mutation that reduces the GAS and/or RS activity, decreased RFO (e.g., raffinose, stachyose) content, increased sucrose content, and/or increased protein content. The mutation can be located at least partially in a GAS and/or RS gene or its homolog or its regulatory region.

公开(公告)号：EP4423282A2

公开(公告)日：2024-09-04

申请号：EP22888434.2

申请日：2022-10-25

申请人： Purdue Research Foundation ,  Doudareva, Natalia ,  Huang, Xing-Qi

发明人： DOUDAREVA, Natalia ,  HUANG, Xing-Qi

IPC分类号： C12N15/52 ,  C12N15/86 ,  C12P7/24

CPC分类号： C12P7/24 ,  C12N9/0004 ,  C12N15/8242 ,  C07K14/415

公开(公告)号：EP4378531A3

公开(公告)日：2024-09-04

申请号：EP24157422.7

申请日：2018-03-09

申请人： Thomas Jefferson University

发明人： ANDREWS, David, W. ,  HOOPER, Douglas, C.

IPC分类号： C12N5/02 ,  C12N5/10 ,  C12N15/09 ,  C12N15/11 ,  C12N15/52 ,  C12N15/113 ,  C12P19/34 ,  C07H21/04 ,  C12Q1/68 ,  A61K31/7105 ,  A61K31/713 ,  A61K39/00 ,  A61P35/00 ,  A61K35/13

CPC分类号： A61K2039/54520130101 ,  A61K2039/5556120130101 ,  C12N2320/3220130101 ,  C12N15/1138 ,  A61K31/713 ,  C12N2310/1120130101 ,  A61P35/00 ,  A61K2039/58520130101 ,  A61K39/0011 ,  A61K31/7105 ,  A61K39/001103 ,  A61K2039/515220130101 ,  A61K35/13

摘要： The present disclosure relates to compositions and methods for treating cancers using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-1R). The AS may be administered to the patients systemically, or may be used to produce an autologous cancer cell vaccine. In embodiments, the AS are provided in an implantable irradiated biodiffusion chamber comprising tumor cells and an effective amount of the AS. The chambers are irradiated and implanted in the abdomen of subjects and stimulate an immune response that attacks tumors distally. The compositions and methods disclosed herein may be used to treat many different kinds of cancer, for example glioblastoma.

公开(公告)号：EP4419660A2

公开(公告)日：2024-08-28

申请号：EP22802475.8

申请日：2022-10-19

申请人： Precision BioSciences, Inc.

发明人： SMITH, James, Jefferson ,  MORRIS, John ,  LAPE, Janel ,  GORSUCH, Cassandra ,  NEMEC, Paige, Scarlett ,  HARRIS, Jason, Richard ,  SHOOP, Wendy

IPC分类号： C12N9/22 ,  C07K14/81 ,  C12N15/90 ,  A61K38/43 ,  C12N15/52

CPC分类号： C07K14/8125 ,  C12N9/22 ,  C12N15/52 ,  C12N15/907 ,  A61K48/005 ,  A61K48/0058 ,  C12N15/86 ,  C12N2750/1414320130101 ,  A61K38/00

公开(公告)号：EP4416299A1

公开(公告)日：2024-08-21

申请号：EP22812735.3

申请日：2022-11-17

申请人： APIX BIOSCIENCES

发明人： WRIGHT, Geraldine ,  MOORE, Elynor ,  BORODINA, Irina ,  DYEKJAER, Jane Dannow ,  ARNESEN, Jonathan Asmund

IPC分类号： C12P33/00 ,  C12N15/52 ,  C12N1/16 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  A23K50/90

CPC分类号： C12P33/00 ,  C12N15/52 ,  C12N9/001 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/88 ,  C12N9/90 ,  A23K50/90 ,  C12N1/16 ,  C12Y504/99017 ,  C12Y201/01041 ,  C12Y103/01021 ,  C12Y103/01072 ,  A23K10/16 ,  A23K20/105 ,  C12R2001/64520210501

公开(公告)号：EP4410984A1

公开(公告)日：2024-08-07

申请号：EP22874472.8

申请日：2022-08-19

申请人： Shanghai Sipeng Technology Ltd.

发明人： TAO, Fei ,  TAN, Chunlin ,  XU, Ping

IPC分类号： C12N15/74 ,  C12N1/21 ,  C12N15/54 ,  C12N15/53 ,  C12N15/52 ,  C12P7/62 ,  C12R1/01

CPC分类号： Y02P20/141

摘要： Provided are a genetically engineered strain for producing polylactic acid and a method for producing polylactic acid. The method includes: synthesizing target gene using D-lactate dehydrogenase gene, propionyl-CoA transferase gene, and polyhydroxyalkanoate synthase gene; and performing double enzymatic cleavage on a vector; purifying; and transforming competent cells to obtain a recombinant plasmid; extracting DNA of the recombinant plasmid; introducing the DNA into an engineering strain, and extracting and verifying to obtain an engineering cell strain; and then culturing the engineering cell strain under light in a culture medium, in which carbon dioxide is introduced; centrifuging; drying; and recycling. According to the present application, by modifying natural cyanobacteria and using a high density fermentation strategy, the biomass of the cyanobacteria is significantly increased. According to the present application, the problem in the related art, i.e., polylactic acid can be only produced by using sugar-derived raw material, is solved.

公开(公告)号：EP4095244B1

公开(公告)日：2024-08-07

申请号：EP21870506.9

申请日：2021-05-20

IPC分类号： C12N9/90 ,  C12N15/52 ,  C12N15/77 ,  C12P13/08

CPC分类号： C12N9/90 ,  C12P13/08 ,  C12R2001/1520210501

公开(公告)号：EP4394034A1

公开(公告)日：2024-07-03

申请号：EP22217314.8

申请日：2022-12-30

申请人： kez.biosolutions GmbH

发明人： RITTNER, Alexander, Dr. ,  DEGEN, Jan

IPC分类号： C12N9/10 ,  C12N15/52 ,  C12N15/82 ,  C12N15/62

CPC分类号： C12N9/1029 ,  C12Y203/01085 ,  C07K2319/0020130101

摘要： The present invention relates to the fields of fatty acid- and polyketide synthesis and protein engineering. In particular, it relates to the provision of engineered acyltransferases having altered substrate specificity as well as means and methods of using acyltransferases of the present invention for polyketide synthesis.