发明公开
- 专利标题： ORTHO SUBSTITUTED PYRIMIDINE COMPOUNDS AS JAK INHIBITORS
- 专利标题（中）： 作为JAK抑制剂的ORTHO取代的嘧啶化合物
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申请号： EP10771368.7申请日： 2010-09-07
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公开(公告)号： EP2475648A1公开(公告)日： 2012-07-18
- 发明人: HARRISON, Richard, John , HOBSON, Andrew , RAMSDEN, Nigel
- 申请人： Cellzome Limited
- 申请人地址： Chesterford Research Park Little Chesterford Cambridge CB10 1XL GB
- 专利权人： Cellzome Limited
- 当前专利权人： Cellzome Limited
- 当前专利权人地址： Chesterford Research Park Little Chesterford Cambridge CB10 1XL GB
- 代理机构： Büchel, Edwin
- 优先权： EP09170083 20090911
- 国际公布： WO2011029807 20110317
- 主分类号： C07D239/48
- IPC分类号： C07D239/48 ; C07D403/12 ; A61K31/505 ; A61K31/506 ; A61P37/00 ; A61P35/00
摘要：
The present invention relates to compounds of formula (I), wherein X
1 to X
3 , R, R
2 to R
7 and AA have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
1 to X
3 , R, R
2 to R
7 and AA have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
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