发明公开
- 专利标题： HIV-1 ANTIBODIES
- 专利标题（中）： HIV-1抗体
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申请号： EP10817555.5申请日： 2010-09-16
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公开(公告)号： EP2477658A2公开(公告)日： 2012-07-25
- 发明人: HAYNES, Barton, F. , TOMARAS, Georgia , SHEN, Shaunna , DIMITROV, Dimiter, S. , ZHU, Zhongyu , HWANG, Kwan-Ki , CHIORAZZI, Nicholas
- 申请人： Duke University , The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services , The Feinstein Institute for Medical Research
- 申请人地址： Durham, NC 27708-0083 US
- 专利权人： Duke University,The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services,The Feinstein Institute for Medical Research
- 当前专利权人： Duke University,The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services,The Feinstein Institute for Medical Research
- 当前专利权人地址： Durham, NC 27708-0083 US
- 代理机构： Atkinson, Peter Birch
- 优先权： US248796P 20091005; US272349P 20090916
- 国际公布： WO2011034582 20110324
- 主分类号： A61K39/42
- IPC分类号： A61K39/42 ; C07K16/10 ; C12N5/07 ; A61P31/18
摘要：
The present invention relates, in general, to HIV-1 specific antibodies and, in particular, to broadly neutralizing HIV-1 specific antibodies that target the gp41 membrane-proximal external region (MPER). The present invention also relates to a cell culture system, more specifically, to a method of rendering chronic lymphocytic leukemia B-cells immortal and to a method of isolating anti-viral antibodies from clones of such cells.
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