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    TUMOR-INFILTRATING T-CELLS FOR USE IN THE TREATMENT OF CANCER
    4.
    发明公开
    TUMOR-INFILTRATING T-CELLS FOR USE IN THE TREATMENT OF CANCER 审中-公开

    公开(公告)号：EP4461825A3

    公开(公告)日：2024-11-20

    申请号：EP24200621.1

    申请日：2018-05-04

    Applicant: Providence Health & Services - Oregon ,  Agonox, Inc.

    Inventor： WEINBERG, Andrew, D. ,  MONTLER, Ryan ,  DUHEN, Thomas ,  DUHEN, Rebekka

    IPC: A61P35/00 ,  A61K35/17 ,  C12N5/07 ,  G01N33/574 ,  C12Q1/6886

    Abstract: Methods are disclosed for treating a subject with a tumor. These methods include administering to the subject a therapeutically effective amount of CD8+CD39+CD103+ T cells. Methods also are disclosed for isolating a nucleic acid encoding a T cell receptor (TCR) that specifically binds a tumor cell antigen. These methods include isolating CD8+CD39+CD103+ T cells from a sample from a subject with a tumor expressing the tumor cell antigen, and cloning a nucleic acid molecule encoding a TCR from the CD8+CD39+CD103+ T cells. In addition, methods are disclosed for expanding CD8+CD39+CD103+ T cells. In additional embodiments, methods are disclosed for determining if a subject with a tumor will respond to a checkpoint inhibitor. The methods include detecting the presence of CD8+CD39+CD103+ T cells in a biological sample from a subject.

    ARTIFICIAL LIVER SYSTEM
    5.
    发明公开
    ARTIFICIAL LIVER SYSTEM 审中-公开

    公开(公告)号：EP4458949A1

    公开(公告)日：2024-11-06

    申请号：EP24186387.7

    申请日：2019-05-22

    Applicant: Morphocell Technologies Inc.

    Inventor： PAUN, Radu Alexandru ,  HABIB, Shawana ,  PAGANELLI, Massimiliano ,  RAGGI, Claudia

    IPC: C12M3/00 ,  A61M1/34 ,  C12N5/07 ,  C12M1/00 ,  C12M1/12

    Abstract: A perfusion bioreactor and a perfusion device. Each perfusion device has a mesh structure, and an encapsulated organ tissue (EOT) disposed in the mesh structure. The EOT has a body with a thickness defined between a first surface of the body and a second surface of the body. The body has at least one channel extending into the body from one of the first and second surfaces to receive a fluid therein. The at least one channel has a diameter selected to diffuse solutes out of the fluid and into the body. The perfusion devices are arranged one adjacent to another and spaced apart from each other along the length of the bioreactor to receive fluid, and to perfuse the fluid to the EOT of each perfusion device and to the at least one channel therein. A method of processing blood plasma and an artificial liver system are also disclosed.

    CELL HOLDING MATERIAL, SENSOR, FRAME MEMBER, AND CELL HOLDING METHOD
    8.
    发明公开
    CELL HOLDING MATERIAL, SENSOR, FRAME MEMBER, AND CELL HOLDING METHOD 审中-实审

    公开(公告)号：EP4424812A1

    公开(公告)日：2024-09-04

    申请号：EP22886934.3

    申请日：2022-10-24

    Applicant: Integriculture Inc.

    Inventor： HATANO, Hiroaki ,  KAWASHIMA, Ikko

    IPC: C12M1/26 ,  C12N5/07 ,  C12Q1/02

    CPC classification number: C12Q1/02 ,  C12N5/06 ,  C12M1/26

    Abstract: A cell holding material capable of holding cells, in which a scaffold to which the cells adhere does not become an obstacle to cell observation, and a cell holding method therefor are provided. A certain embodiment of the present invention is a cell holding material, including a frame member for surrounding all or at least part of a planned holding region capable of holding a cell population obtained by aggregating multiple cells, and the cell population in a form of membrane occupying at least part of the planned holding region and being held by the frame member, in which at least part of a margin of the cell population is brought into contact with the frame member, and further a portion occupying the planned holding region in the cell population is in a state of being hung without physical support.

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