发明公开
EP2481808A1 AMELIORATION OF METABOLIC SYNDROME OR METHOD FOR SCREENING FOR AMELIORATING AGENT FOR METABOLIC SYNDROME UTILIZING PHYSIOLOGICAL FUNCTION OF SPHINGOMYELIN SYNTHASE SMS2
审中-公开
代谢综合征或方法，以筛选缓解代谢综合征救济资金使用鞘磷脂合成酶SMS2生理功能
- 专利标题： AMELIORATION OF METABOLIC SYNDROME OR METHOD FOR SCREENING FOR AMELIORATING AGENT FOR METABOLIC SYNDROME UTILIZING PHYSIOLOGICAL FUNCTION OF SPHINGOMYELIN SYNTHASE SMS2
- 专利标题（中）： 代谢综合征或方法，以筛选缓解代谢综合征救济资金使用鞘磷脂合成酶SMS2生理功能
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申请号： EP10818555.4申请日： 2010-09-22
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公开(公告)号： EP2481808A1公开(公告)日： 2012-08-01
- 发明人: MITSUTAKE, Susumu , IGARASHI, Yasuyuki , ZAMA, Kota , YOSHIDA, Tetsuya , TANAKA, Yoshikazu , TAKEMOTO, Hiroshi
- 申请人： National University Corporation Hokkaido University , Shionogi & Co., Ltd.
- 申请人地址： 8, Kita 8-jyo Nishi 5-chome Kita-ku Sapporo-shi, Hokkaido 060-0808 JP
- 专利权人： National University Corporation Hokkaido University,Shionogi & Co., Ltd.
- 当前专利权人： National University Corporation Hokkaido University,Shionogi & Co., Ltd.
- 当前专利权人地址： 8, Kita 8-jyo Nishi 5-chome Kita-ku Sapporo-shi, Hokkaido 060-0808 JP
- 代理机构： Vossius & Partner
- 优先权： JP2009219751 20090924
- 国际公布： WO2011036878 20110331
- 主分类号： C12Q1/48
- IPC分类号： C12Q1/48 ; C12N5/10 ; G01N33/15 ; G01N33/50 ; G01N33/68 ; C12N15/09
摘要：
Disclosed is a method for screening for a medicinal agent that can decrease a body weight, a medicinal agent that can reduce a visceral fat, a medicinal agent that can reduce a triglyceride in the liver, and a medicinal agent that can ameliorate obesity and fatty liver. The method involves a step of measuring the inhibitory activity of a candidate substance on a sphingomyelin synthase, wherein the candidate substance is determined to have at least one function selected from the group consisting of an anti-obesity agent, a visceral fat-reducing agent, a fatty liver-treating agent and an adiponectin expression enhancer when the candidate substance has an inhibitory activity on the sphingomyelin synthase.
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