公开(公告)号：EP4446425A1

公开(公告)日：2024-10-16

申请号：EP22904342.7

申请日：2022-12-09

申请人： National University Corporation Hokkaido University ,  Anicom Holdings, Inc.

发明人： YAMAZAKI, Jumpei

IPC分类号： C12Q1/68

摘要： The present invention is a post-chemotherapy prognosis prediction method for a canine with lymphoma, including: a measurement step of measuring a methylation rate of one or more CpG sites selected from the group consisting of Chr4: 29559893 and Chr1: 14232692, in DNA recovered from a biological sample collected from a canine as a prediction target; and a prediction step of predicting a post-chemotherapy prognosis for a canine with lymphoma, based on the methylation rate measured in the measurement step and a preset reference value, in which the reference value is a value for differentiating between a canine having a favorable post-chemotherapy prognosis and a canine having a poor post-chemotherapy prognosis, which is set for each methylation rate of each CpG site.

公开(公告)号：EP4410292A1

公开(公告)日：2024-08-07

申请号：EP22876159.9

申请日：2022-09-27

申请人： Shionogi & Co., Ltd ,  National University Corporation Hokkaido University

发明人： TACHIBANA Yuki ,  UEHARA Shota ,  UNOH Yuto ,  NAKAHARA Kenji ,  TAODA Yoshiyuki ,  KASAMATSU Koji ,  YAMATSU Yukiko ,  ANDO Shigeru ,  FUKAO Keita ,  NOBORI Haruaki ,  KURODA Takayuki ,  TOBA Shinsuke ,  UEMURA Kentaro ,  MARUYAMA Yuki ,  SASAKI Michihito ,  SAWA Hirofumi

IPC分类号： A61K31/5355 ,  A61K31/53 ,  A61K31/5377 ,  A61P31/12 ,  A61P31/14 ,  A61P43/00

CPC分类号： A61P31/12 ,  A61P43/00 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/53 ,  A61P31/14

摘要： The present invention provides a pharmaceutical composition comprising a compound exhibiting coronavirus proliferation inhibitory activity.

A pharmaceutical composition comprising a compound represented by the formula: wherein Y is N; R1 is substituted or unsubstituted aromatic heterocyclyl; R2 is substituted or unsubstituted 6-membered aromatic carbocyclyl; R3 is substituted or unsubstituted aromatic heterocyclyl; -X- is -NH-; m is 0 or 1; R5a is a hydrogen atom; R5b is a hydrogen atom; n is 1; R4a is a hydrogen atom; and R4b is a hydrogen atom, or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4393507A1

公开(公告)日：2024-07-03

申请号：EP22848863.1

申请日：2022-02-10

申请人： National University Corporation Hokkaido University

发明人： KADOYA Ken ,  YAMAMOTO Yasuhiro

IPC分类号： A61K45/00 ,  A61K31/155 ,  A61K31/395 ,  A61K31/42 ,  A61K31/5377 ,  A61K39/395 ,  A61P25/02 ,  A61P43/00

CPC分类号： A61P43/00 ,  A61K39/395 ,  A61K31/5377 ,  A61K45/00 ,  A61K31/42 ,  A61P25/02 ,  A61K31/395 ,  A61K31/155

摘要： The present invention provides a pharmaceutical composition for treating peripheral nerve injury, said pharmaceutical composition comprising a substance that inhibits the formation of neutrophil extracellular traps (NETs) outside the parenchyma of injured peripheral nerves, for example, a substance that inhibits the accumulation of neutrophils in injured peripheral nerves, a substance that suppresses the expression or inhibits the function of macrophage migration inhibitory factor (MIF), etc. The present invention further provides a method for evaluating the peripheral nerve regeneration-promoting activity of a test substance using, as an indicator, the activity to inhibit the formation of NETs outside the parenchyma of injured peripheral nerves, for example, the activity to inhibit the accumulation of neutrophils in injured peripheral nerves, the activity to suppress the expression of MIF or the activity to inhibit the function thereof, etc.

公开(公告)号：EP4375735A1

公开(公告)日：2024-05-29

申请号：EP22845930.1

申请日：2022-07-19

申请人： National Institute of Information and Communications Technology ,  National University Corporation Hokkaido University

发明人： FUJIWARA Mikio ,  TAKEOKA Masahiro ,  SASAKI Masahide ,  TOMITA Akihisa

IPC分类号： G02F1/01 ,  G01N21/45

CPC分类号： G01N21/45 ,  G02F1/01

摘要： Provided is a high-accurate calibration method of a phase modulator and a balanced photodetector for quantum key distribution. A phase modulator calibration method according to the present invention includes steps of: providing a first delay interferometer (10) to be used as a phase calibration reference and a second delay interferometer (20) in which a phase modulator (30) to be calibrated is installed in an optical path; for each of the first and second delay interferometers, measuring a delay time based on a time interval between pulses split from one input pulse and synchronizing the delay time with a cycle of a transmission clock; for the first delay interferometer (10), adjusting a phase difference so that input continuous-wave laser light produces an intensity-enhancing interference at an output; and determining the control signal with a calibration circuitry (100) formed by connecting the first delay interferometer (10) as a front stage and the second delay interferometer (20) as a rear stage in a cascaded manner.

公开(公告)号：EP4279494A1

公开(公告)日：2023-11-22

申请号：EP21906417.7

申请日：2021-12-06

申请人： National University Corporation Hokkaido University

发明人： OGAWA, Mikako ,  TAKAKURA, Hideo ,  MATSUHIRO, Shino ,  INANAMI, Osamu

IPC分类号： C07F7/02 ,  A61K31/409 ,  A61K31/695 ,  A61K41/00 ,  A61P9/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/10 ,  A61P31/04 ,  A61P35/00

摘要： An object is to provide a method for decomposing a photosensitive dye with an energy beam capable of penetrating deeper into a living body than near-infrared light and activating the photosensitive dye and a photosensitive dye having high photosensitivity. Provided is a method for decomposing a compound represented by Formula (1), the method including irradiating the compound with X-rays in a presence of an electron donor:

(in Formula (1), R 111 , R 121 , R 131 , and R 141 each independently represent a monovalent organic group; p, q, r, and s each independently represent an integer of 0 or 1 to 4; in the case where two or more R 111 , R 121 , R 131 , and R 141 are present, they may be identical to or different from one another or may be bonded to one another to form a ring; A 101 represents a monovalent organic group; and A 102 represents a hydrogen atom or a monovalent organic group).

公开(公告)号：EP4276467A1

公开(公告)日：2023-11-15

申请号：EP23172990.6

申请日：2023-05-12

申请人： National University Corporation Hokkaido University ,  SYSMEX CORPORATION

发明人： KINJO, Masataka ,  GANGULY, Akshay ,  RAMASWAMY, Lausonia

IPC分类号： G01N33/58 ,  G01N33/86

摘要： Disclosed is a method for obtaining information on von Willebrand factor (VWF), comprising the following steps: denaturing, with urea, VWF contained in a biological sample; fluorescently labeling the denatured VWF using a capturing agent that comprises a fluorescent substance and binds to the denatured VWF; and obtaining information on the size of the fluorescently-labeled VWF by fluorescence correlation spectroscopy or fluorescence cross-correlation spectroscopy.

公开(公告)号：EP4238982A1

公开(公告)日：2023-09-06

申请号：EP21863087.9

申请日：2021-08-18

申请人： NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

发明人： MATSUDA, Tadashi ,  ORITANI, Kenji ,  KITAI, Yuichi

IPC分类号： C07K7/08 ,  A61K38/08 ,  A61K47/65 ,  A61P35/00 ,  C07K14/47 ,  C07K14/82 ,  C12N15/00

摘要： The present invention provides a peptide that consists of an amino acid sequence with 20 or fewer residues containing at least one amino acid sequence selected from the group consisting of the amino acid sequence represented in SEQ ID NO: 1, the amino acid sequence represented in SEQ ID NO: 2 and the amino acid sequence represented in SEQ ID NO: 38, the peptide having an activity to inhibit proliferation of a tumor cell or having an activity to inhibit binding between an epidermal growth factor receptor and a signal-transducing adaptor family member-2 (STAP-2); a peptide with a cell-penetrating peptide added to a terminus of the above peptide with or without a linker sequence interposed between the cell-penetrating peptide and the terminus; and pharmaceutical compositions containing any of these peptides.

公开(公告)号：EP4205882A1

公开(公告)日：2023-07-05

申请号：EP21861674.6

申请日：2021-08-26

申请人： National University Corporation Hokkaido University

发明人： YONEZAWA, Tetsu

IPC分类号： B22F1/102 ,  B22F7/04 ,  B22F9/00 ,  C22C1/04 ,  B22F3/10 ,  B22F1/00

摘要： Disclosed is oxide-containing copper fine particles including Cu 64 O and optionally Cu 2 O and coated with a carboxylic acid, wherein a mass ratio of Cu 64 O to a total mass of Cu, Cu 64 O and Cu 2 O is 0.5 to 2.0% by mass.

公开(公告)号：EP4082332A1

公开(公告)日：2022-11-02

申请号：EP20907296.6

申请日：2020-12-07

申请人： Kikkoman Corporation ,  National University Corporation Hokkaido University

发明人： ATARASHI, Hiroki ,  NAKAHARA, Kenji

IPC分类号： A01H5/00 ,  A01H5/08 ,  A01H5/10 ,  C12N15/54 ,  A01H6/82

摘要： The present invention addresses the problem of providing: a solanaceous plant and a solanaceous plant cell that have resistance to tomato spotted wilt virus (TSWV) and that have the property of inhibiting TSWV infection, the property of suppressing the propagation of TSWV after infection, and/or the property of suppressing the onset of the symptoms of TSWV infection; and a method for producing the solanaceous plant. The present invention provides a solanaceous plant that has resistance to TSWV, in which at least one gene selected from the group consisting of receptor-like kinase RLK genes and homologous genes thereof has a mutation, and in which as a result of the mutation, either the expression of the gene having the mutation is suppressed or a protein encoded by the gene having the mutation is non-functional with respect to TSWV.

公开(公告)号：EP4051807A1

公开(公告)日：2022-09-07

申请号：EP20880921.0

申请日：2020-10-30

申请人： Showa Denko Materials (America), Inc. ,  Showa Denko Materials Co., Ltd. ,  National University Corporation Hokkaido University

发明人： MURAKAMI, Taku ,  OSAWA, Takahiro

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/571