发明公开
- 专利标题： VARIANT LOVD POLYPEPTIDES AND THEIR USES
- 专利标题（中）： VARIANT LOV-D多肽和用途
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申请号： EP10821065申请日： 2010-09-24
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公开(公告)号： EP2483292A4公开(公告)日： 2013-05-01
- 发明人: GILSON LYNNE , COLLIER STEVEN JAMES , SUKUMARAN JOLY , YEO WAN LIN , ALVISO OSCAR , TEO EE LING , WILSON ROBERT JOHN , XU JUNYE
- 申请人： CODEXIS INC
- 专利权人： CODEXIS INC
- 当前专利权人： CODEXIS INC
- 优先权： US24725309 2009-09-30; US24727409 2009-09-30
- 主分类号： C07K14/00
- IPC分类号： C07K14/00 ; C12N9/10 ; C12P7/00
摘要：
Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
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