公开(公告)号：EP2483292A4

公开(公告)日：2013-05-01

申请号：EP10821065

申请日：2010-09-24

申请人： CODEXIS INC

发明人： GILSON LYNNE ,  COLLIER STEVEN JAMES ,  SUKUMARAN JOLY ,  YEO WAN LIN ,  ALVISO OSCAR ,  TEO EE LING ,  WILSON ROBERT JOHN ,  XU JUNYE

IPC分类号： C07K14/00 ,  C12N9/10 ,  C12P7/00

CPC分类号： C12P17/06 ,  C07K14/00 ,  C12N9/1025 ,  C12N9/1029 ,  C12N15/52 ,  C12P7/62 ,  C12Y203/01 ,  Y02P20/52

摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.

公开(公告)号：EP2451951A4

公开(公告)日：2013-01-09

申请号：EP09845944

申请日：2009-09-18

申请人： CODEXIS INC

发明人： COLBECK JEFFREY ,  MIJTS BENJAMIN ,  GIVER LORRAINE JOAN ,  FOX RICHARD J ,  MITCHELL VESNA ,  PAK BUMSHIK ROBERT ,  GILSON LYNNE

IPC分类号： C12N15/10 ,  C12Q1/68 ,  C40B40/06 ,  C40B50/06

CPC分类号： C12N15/102 ,  C12N15/1093 ,  C40B40/06 ,  C40B50/06