发明公开
EP2484363A1 (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide
审中-公开
（2S，3R）-N-（2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2]辛-3-基）-5-甲基噻吩-2-甲酰胺
- 专利标题： (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide
- 专利标题（中）： （2S，3R）-N-（2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2]辛-3-基）-5-甲基噻吩-2-甲酰胺
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申请号： EP12164661.6申请日： 2008-08-01
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公开(公告)号： EP2484363A1公开(公告)日： 2012-08-08
- 发明人: Mazurov,, Anatoly A
- 申请人： Targacept, Inc. , Medical College of Georgia Research Institute, Inc
- 申请人地址： 200 East First Street, Suite 300 Winston-Salem, NC 27101 US
- 专利权人： Targacept, Inc.,Medical College of Georgia Research Institute, Inc
- 当前专利权人： Targacept, Inc.,Medical College of Georgia Research Institute, Inc
- 当前专利权人地址： 200 East First Street, Suite 300 Winston-Salem, NC 27101 US
- 代理机构： Crowhurst, Charlotte Waveney
- 优先权： US953610P 20070802; US953613P 20070802; US953614P 20070802; US971654P 20070912
- 主分类号： A61K31/4545
- IPC分类号： A61K31/4545 ; A61P25/00 ; A61P25/02 ; A61P25/14 ; A61P25/16 ; A61P25/18 ; A61P25/22 ; A61P25/24 ; A61P25/28 ; A61P29/00 ; A61P35/00 ; A61P43/00 ; A61K45/06 ; C07D453/02
摘要：
The present invention related to the α7-selective ligand (2S,3R)-N-(2-((3-pyridinyl)methyl)-l-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide or a pharmaceutical acceptable salt thereof and (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide or a pharmaceutical acceptable salt thereof, substantially free of (2R,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide or a pharmaceutical acceptable salt thereof, (2S,3S)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide or a pharmaceutical acceptable salt thereof and (2R,3S)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene -2-carboxamide or a pharmaceutical acceptable salt thereof.
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