公开(公告)号：EP2254598B1

公开(公告)日：2013-07-10

申请号：EP09709577.2

申请日：2009-02-13

申请人： Targacept, Inc.

发明人： BENCHERIF, Merouane ,  GATTO, Gregory, J. ,  HAUSER, Terry ,  JORDAN, Kristen G. ,  LETCHWORTH, Sharon R.

IPC分类号： A61K45/06

CPC分类号： A61K45/06

公开(公告)号：EP2592083A1

公开(公告)日：2013-05-15

申请号：EP11782976.2

申请日：2011-05-20

申请人： Shenzhen Salubris Pharmaceuticals Co., Ltd. ,  Shanghai Institute of Pharmaceutical Industry

发明人： LI, Jianqi ,  ZHANG, Zixue ,  XIE, Peng ,  ZHANG, Qingwei

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D487/04

摘要： Fused quinazoline derivatives and uses thereof as protein tyrosine kinase inhibitors and aurora kinase inhibitors are disclosed. Said protein tyrosine kinase inhibitors and aurora kinase inhibitors can be used in treating cancers, leukaemia and the diseases relevant to differentiation and proliferation. Said protein tyrosine kinase and aurora kinase dual inhibitors are the compounds represented by the following general formula or salts thereof.

摘要翻译： 公开了熔融喹唑啉衍生物及其作为蛋白质酪氨酸激酶抑制剂和极光激酶抑制剂的用途。 所述蛋白酪氨酸激酶抑制剂和极光激酶抑制剂可用于治疗癌症，白血病和与分化和增殖相关的疾病。 所述蛋白酪氨酸激酶和极光激酶双重抑制剂是由以下通式表示的化合物或其盐。

公开(公告)号：EP2591130A2

公开(公告)日：2013-05-15

申请号：EP11803831.4

申请日：2011-07-08

申请人： Research Institute Of Industrial Science&Technology

发明人： CHON, Uong ,  KWON, Oh Joon ,  KIM, Ki Hong ,  SONG, Chang Ho ,  HAN, Gi Chun ,  KIM, Ki Young

IPC分类号： C22B3/38 ,  C22B26/12 ,  C22B7/00 ,  C01B25/30

CPC分类号： C22B26/12 ,  C01B25/30 ,  C22B3/44 ,  C22B7/006 ,  Y02P10/234

摘要： The present invention relates to a method of extracting lithium from a lithium bearing solution. More specifically, the present invention provides a method of economical extraction of lithium from a lithium bearing solution by adding a phosphorous supplying material to the solution to precipitate lithium phosphate from the dissolved lithium.

公开(公告)号：EP2570417A1

公开(公告)日：2013-03-20

申请号：EP11780039.1

申请日：2011-03-23

申请人： Tianjin Institute Of Pharmaceutical Research

发明人： LIU, Dengke ,  LIU, Ying ,  YUE, Nan ,  CHEN, Furong ,  TAN, Chubing ,  ZHOU, Yunsong ,  LIU, Peng ,  ZHAO, Yigui ,  ZHI, Deguang ,  LIU, Mo ,  LIU, Bingni ,  HUANG, Changjiang ,  TANG, Lida

IPC分类号： C07D495/04 ,  A61K31/4365 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10

CPC分类号： C07D495/04 ,  A61K9/0019 ,  A61K9/1652 ,  A61K9/19 ,  A61K9/2054 ,  A61K9/2059 ,  A61K47/10 ,  A61K47/26

摘要： A compound with the structure of the formula (I) or a pharmaceutically acceptable salt, a preparation method and use thereof are disclosed in the present invention, wherein R is cyano group. The compound provided by the present invention has an antiplatelet aggregation activity and can be used in preparing a medicament for preventing or treating cardiac and cerebral vascular diseases such as coronary artery syndromes, myocardial infarction and myocardial ischemia which are caused by platelet aggregation.

摘要翻译： 在本发明中公开了具有式（I）结构的化合物或其药学上可接受的盐，其中R是氰基。 本发明提供的化合物具有抗血小板聚集活性，可用于制备预防或治疗由血小板聚集引起的心脑血管疾病如冠状动脉综合征，心肌梗死和心肌缺血的药物。

公开(公告)号：EP2544690A2

公开(公告)日：2013-01-16

申请号：EP11753832.2

申请日：2011-03-04

申请人： Targacept Inc.

发明人： TOLER, Steven M. ,  HOSFORD, David A. ,  LIPPIELLO, Patrick M. ,  DUNBAR, Geoffrey Charles ,  CALDWELL, William Scott ,  HAMEDANI, Parviz ,  BENCHERIF, Merouane

IPC分类号： A61K31/506 ,  A61K31/505 ,  C07D403/02 ,  C07D239/26 ,  A61P1/00 ,  A61P25/00

CPC分类号： A61K31/506 ,  A61K31/505 ,  A61K45/06 ,  C07D403/06 ,  A61K2300/00

摘要： The present invention relates to methods of treating constipation and enhancing colonic motility by administration of 5-((E)-2 pyrrolidin-3-ylvinyl)pyrimidine or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及通过施用5 - （（E）-2-吡咯烷-3-基乙烯基）嘧啶或其药学上可接受的盐来治疗便秘和增强结肠运动性的方法。

公开(公告)号：EP2481739A1

公开(公告)日：2012-08-01

申请号：EP10818228.8

申请日：2010-09-14

申请人： Jiangsu Hengrui Medicine Co., Ltd. ,  Shanghai Hengrui Pharmaceutical Co. Ltd.

发明人： TANG, Peng Cho ,  ZHANG, Nong ,  ZHANG, Baolei ,  WANG, Weimin ,  ZHENG, Hao ,  WU, Lin

IPC分类号： C07D475/00 ,  C07D519/00 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383 ,  A61P35/00 ,  A61P31/00 ,  A61P29/00 ,  A61P37/00

CPC分类号： C07D475/00 ,  C07D519/00

摘要： Dihydroperidinone derivatives, preparation process and pharmaceutical use thereof are disclosed. Specially, new dihydroperidinone derivatives represented by general formula (I), wherein each substituent of the general formula (I) is defined as in the description, their preparation process, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors are disclosed.

摘要翻译： 公开了二氢哌啶酮衍生物，其制备方法和药物用途。 特别地，由通式（I）表示的新的二氢哌啶酮衍生物，其中通式（I）的每个取代基如说明书中所定义，其制备方法，包含所述衍生物的药物组合物及其作为治疗剂的用途，特别是作为Plk激酶 公开了抑制剂。

公开(公告)号：EP2481720A2

公开(公告)日：2012-08-01

申请号：EP12166051.8

申请日：2009-04-09

申请人： Mexichem Amanco Holding S.A. de C.V.

发明人： Sharratt, Andrew, Paul ,  Smith, John, William ,  McGuiness, Claire

IPC分类号： C07C17/23 ,  C07C17/25 ,  C07C21/18

CPC分类号： C07C17/204 ,  C07C17/04 ,  C07C17/206 ,  C07C17/25 ,  C07C17/275 ,  C07C19/08 ,  C07C19/10 ,  C07C21/18 ,  C07C21/04 ,  C07C19/01

摘要： The invention provides a process for preparing 3,3,3-trifluoropropene (1243zf), the process comprising contacting a compound of formula CX 3 CH 2 CH 2 X or CX 3 CH=CH 2 , with hydrogen fluoride (HF) in the presence of a zinc/chromia catalyst, wherein each X independently is F, Cl, Br or I, provided that in the compound of formula CX 3 CH=CH 2 , at least one X is not F.

摘要翻译： 本发明提供一种制备3,3,3-三氟丙烯（1243zf）的方法，该方法包括使式CX 3 CH 2 CH 2 X或CX 3 CH = CH 2的化合物与氟化氢（HF）在存在下 的锌/氧化铬催化剂，其中每个X独立地为F，Cl，Br或I，条件是在式CX 3 CH = CH 2的化合物中，至少一个X不为F.

公开(公告)号：EP2481572A1

公开(公告)日：2012-08-01

申请号：EP09849665.6

申请日：2009-09-25

申请人： Ocean's King Lighting Science&Technology Co., Ltd.

发明人： ZHOU, Mingjie ,  MA, Wenbo

IPC分类号： B32B17/06 ,  C03C14/00 ,  C03C4/12

CPC分类号： C03C4/12 ,  C03C14/004 ,  C03C2214/04 ,  C09K11/025 ,  C09K11/08 ,  H01L33/501 ,  H01L33/508 ,  Y10T428/239

摘要： A luminescent glass comprises glass matrix. Said glass matrix comprises a glass part and a complex part of glass and fluorescent powder, which is embedded in said glass part. Said complex part of glass and fluorescent powder comprises glass material and fluorescent powder dispersed in said glass material. Said fluorescent powder is of nitrides or oxynitrides series. A method for producing the luminescent glass and a luminescent device comprising the luminescent glass are also provided. The luminescent glass and the luminescent device have good luminescence reliability, high luminescence stability and long service life. The method can be carried out at a relatively low temperature.

摘要翻译： 发光玻璃包括玻璃基质。 所述玻璃基体包括玻璃部分和嵌入所述玻璃部分中的玻璃和荧光粉末的复合部分。 玻璃和荧光粉末的所述复合部分包括分散在所述玻璃材料中的玻璃材料和荧光粉。 所述荧光粉是氮化物或氧氮化物系列。 还提供了制造发光玻璃的方法和包括发光玻璃的发光装置。 发光玻璃和发光装置具有良好的发光可靠性，高发光稳定性和长使用寿命。 该方法可以在相对较低的温度下进行。

公开(公告)号：EP2471983A1

公开(公告)日：2012-07-04

申请号：EP11177599.5

申请日：2011-08-15

申请人： Zhong, Zhou

发明人： Zhong, Zhou

IPC分类号： D01D1/02 ,  D01F6/60 ,  C08G69/32

CPC分类号： D01F6/805 ,  B29C47/0014 ,  C08G69/32 ,  D01D1/02 ,  D01F6/605

摘要： The present invention provides a method for preparing meta-aramid fibers, comprising the steps of polymerization, neutralization and spinning using m-phenylenediamine and isophthaloyl chloride as raw materials, characterized in that the neutralizing agent is added in an amount that is sufficient only for neutralizing a part of hydrogen chloride, so that the resultant spin dope of polyisophthaloyl metaphenylene diamine contains salts produced by the neutralization reaction and a part of unneutralized hydrogen chloride. The method of the invention has a short production line with reduced amount of the neutralizing agent, therefore both the costs of raw materials and the production energy consumption are saved. The fibers prepared according to the method of the invention have reduced gray scale to improve the electrical insulation properties of the fibers.

摘要翻译： 本发明提供了一种间位芳族聚酰胺纤维的制备方法，包括以间苯二胺和间苯二甲酰氯为原料进行聚合，中和和纺丝的步骤，其特征在于中和剂的添加量仅为中和 一部分氯化氢，使得聚邻苯二甲酰邻二代苯二胺的所得纺丝原液含有通过中和反应产生的盐和一部分未中和氯化氢。 本发明的方法具有生产线短，中和剂量少的原料，因此可节省原料成本和生产能耗。 根据本发明的方法制备的纤维具有降低的灰度，以改善纤维的电绝缘性能。

公开(公告)号：EP2459545A2

公开(公告)日：2012-06-06

申请号：EP10749674.7

申请日：2010-07-30

申请人： South Bank University Enterprises Limited

发明人： SAHA, Basudeb ,  AMBROZIAK, Krzysztof ,  SHERRINGTON, David, C. ,  MBELECK, Rene

IPC分类号： C07D301/19 ,  C07D303/06 ,  B07B1/46 ,  B01J19/32 ,  B01D3/00 ,  B01J31/16

CPC分类号： B65D33/00 ,  B01D3/009 ,  B01J19/32 ,  B01J31/165 ,  B01J31/1658 ,  B01J31/181 ,  B01J31/1815 ,  B01J2208/00814 ,  B01J2219/32279 ,  B01J2219/32408 ,  B01J2219/32466 ,  B01J2219/32483 ,  B01J2231/72 ,  B01J2523/69 ,  B01J2531/16 ,  B01J2531/46 ,  B01J2531/56 ,  B01J2531/64 ,  B01J2531/66 ,  B01J2531/72 ,  B01J2531/821 ,  B01J2531/842 ,  B07B1/46 ,  C07D301/19 ,  C07D303/06 ,  Y02P20/127

摘要： The present invention provides a continuous process for the epoxidation of an olefinic compound with an oxidant, which process comprises reaction of an olefinic compound with an oxidant in the presence of a catalyst in an apparatus that comprises a reactive distillation column, which column comprises (i) a reactive section, which comprises the catalyst (ii) a rectifying section situated above the reactive section and adapted to allow separation of reagents and/or by-products from products (ix) a stripping section situated below the reactive section and adapted to allow separation of product from reagents and/or by-products (x) a vessel situated below the stripping section and adapted to provide a source of heat for the column and in which initial vaporization of one or more of the reagents can occur, wherein the temperature in the reactive section (i) is a temperature at which the reaction between the olefinic compound and the oxidant takes place and the temperature in the stripping section (iii) is higher than the temperature in the rectifying section (ii).

摘要翻译： 本发明提供了一种用氧化剂环氧化烯烃化合物的连续方法，该方法包括烯烃化合物与氧化剂在催化剂存在下在包含反应性蒸馏塔的设备中反应，该设备包含（i ）包含催化剂的反应部分;（ii）位于反应部分上方并适于允许从反应部分分离反应物和/或副产物的精馏部分;（ix）位于反应部分下方的汽提部分， 产品与试剂和/或副产物的分离;（x）位于汽提区段下方并适于为塔提供热源并且其中一种或多种试剂可能发生初始蒸发的容器，其中温度 在反应段（i）中是发生烯烃化合物和氧化剂之间的反应的温度和反萃取段中的温度 （iii）高于精馏段（ii）中的温度。