A method of treating an intravascular thrombus is disclosed. The method comprises providing a guide wire and catheter with at least one inductive element within a blood vessel to a distal location associated with the thrombus; and providing electromagnetic energy via at least one inductive element to the thrombus to cause thrombolysis. Medicated magnetic particles can be endovascularly localized and concentrated to the vascular territory affected by thrombosis. The method can also include providing an actuated segment on the distal portion of the guide wire to impart mechanical energy at the site of distal thrombus to work adjunctively with the inductive element facilitating thrombolysis. The guide wire can be shaped using an external guide wire shaping method to enable the user to impart precisely defined complex shapes to the distal aspect of the guide wire. The method can also include providing a support mechanism for the catheter using an actuator segment incorporated into or onto the catheter to aid in the proximal support for far distal localization of the guide wire mounted induction element and actuator.