发明公开
- 专利标题： INHIBITORS OF THE MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1
- 专利标题（中）： 微粒体前列腺素E2合成酶2抑制剂
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申请号： EP10765442.8申请日： 2010-10-14
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公开(公告)号： EP2491007A1公开(公告)日： 2012-08-29
- 发明人: PRIEPKE, Henning , DOODS, Henri , KUELZER, Raimund , PFAU, Roland , STENKAMP, Dirk , ROENN, Robert , PELCMAN, Benjamin
- 申请人： Boehringer Ingelheim International GmbH
- 申请人地址： Binger Strasse 173 55216 Ingelheim am Rhein DE
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： Binger Strasse 173 55216 Ingelheim am Rhein DE
- 代理机构： Hammann, Heinz
- 优先权： EP09173872 20091023
- 国际公布： WO2011048004 20110428
- 主分类号： C07C233/76
- IPC分类号： C07C233/76 ; C07C311/14 ; C07D213/81 ; C07D213/82 ; C07D333/38 ; C07D295/155 ; A61P19/02 ; A61P29/00 ; A61P11/06 ; A61K31/167 ; A61K31/381 ; A61K31/44 ; A61K31/445
摘要：
This invention relates to compounds of formula I, their use as inhibitors of the microsomal prostaglandin E
2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions such as inflammatory/nociceptive pain. A, M, R
1 , R
2 , R
7 ' R
a , R
b , Q
3 , Q
4 , Q
6 , Z
2 , Z
4 , Z
5 , Z
6 and W have meanings given in the description.
2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions such as inflammatory/nociceptive pain. A, M, R
1 , R
2 , R
7 ' R
a , R
b , Q
3 , Q
4 , Q
6 , Z
2 , Z
4 , Z
5 , Z
6 and W have meanings given in the description.
公开/授权文献
- EP2491007B1 Inhibitors of the microsomal prostaglandin E2 synthase-1 公开/授权日：2013-09-25
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