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公开(公告)号：EP2491007B1
公开(公告)日：2013-09-25
申请号：EP10765442.8
申请日：2010-10-14
发明人： PRIEPKE, Henning , DOODS, Henri , KUELZER, Raimund , PFAU, Roland , STENKAMP, Dirk , ROENN, Robert , PELCMAN, Benjamin
IPC分类号： C07C233/76 , C07C311/14 , C07D213/81 , C07D213/82 , C07D333/38 , C07D295/155 , A61P19/02 , A61P29/00 , A61P11/06 , A61K31/167 , A61K31/381 , A61K31/44 , A61K31/445
CPC分类号： C07D213/82 , C07C237/42 , C07C237/44 , C07C255/23 , C07C255/60 , C07C311/14 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/10 , C07D207/22 , C07D207/34 , C07D209/08 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/38 , C07D213/40 , C07D213/75 , C07D213/81 , C07D215/42 , C07D237/30 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D295/15 , C07D295/155 , C07D307/20 , C07D307/24 , C07D309/12 , C07D309/14 , C07D333/38 , C07D335/02 , C07D417/04
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2.发明公开2-(ARYLAMINO)-3H-IMIDAZO[4,5-B]PYRIDINE-6-CARBOXAMIDE DERIVATIVES AND THEIR USE AS MPGES-1 INHIBITORS 审中-公开2-（芳基氨基）-3H-咪唑并〔4,5-b〕吡啶-6-甲酰胺衍生物及其作为抑制剂的mPGES-1
公开(公告)号：EP2606046A1
公开(公告)日：2013-06-26
申请号：EP11751853.0
申请日：2011-08-19
发明人： PRIEPKE, Henning , DOODS, Henri , KUELZER, Raimund , PFAU, Roland , STENKAMP, Dirk , PELCMAN, Benjamin , ROENN, Robert , LUBRIKS, Dimitrijs , SUNA, Edgars
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00
CPC分类号： C07D471/04
摘要： This invention relates to compounds of formula (I) their use as inhibitors of the microsomal prostaglandin E
2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R
1 , R
2 , R
6 , R
7 have meanings given in the description.-
3.发明公开
公开(公告)号：EP2403852A1
公开(公告)日：2012-01-11
申请号：EP10706659.9
申请日：2010-03-05
发明人： PFAU, Roland , ARNDT, Kirsten , DOODS, Henri , KLINDER, Klaus , KUELZER, Raimund , LUBRIKS, Dimitrijs , MACK, Juergen , PELCMAN, Benjamin , PRIEPKE, Henning , ROENN, Robert , STENKAMP, Dirk , SUNA, Edgars
IPC分类号： C07D471/04 , A61K31/4188 , A61P11/00 , A61P29/00
CPC分类号： C07D235/30 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds of general formula (I) in which A, L, M, Q
2 , Q
3 , Q
4 , R
1 , R
5 , R
a , R
b , R
c , W, X, Y, Z
1 , Z
2 , Z
3 are defined in the description, the salts thereof, particularly the physiologically acceptable salts thereof. The compounds are of potential utility in the treatment and/or prevention of inflammatory diseases and associated conditions, in particular, in the treatment and/or prevention of pain. The invention also relates to the use of such compounds as medicaments, to pharmaceutical compositions containing them, and to their preparation.-
4.发明授权
公开(公告)号：EP2649052B1
公开(公告)日：2014-10-22
申请号：EP11796671.3
申请日：2011-12-09
发明人： PRIEPKE, Henning , KUELZER, Raimund , MACK, Juergen , PFAU, Roland , STENKAMP, Dirk , PELCMAN, Benjamin , ROENN, Robert , LUBRIKS, Dimitrijs , SUNA, Edgars
IPC分类号： C07D235/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , A61K31/4184 , A61P29/00
CPC分类号： C07D403/04 , C07D235/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12
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公开(公告)号：EP2491007A1
公开(公告)日：2012-08-29
申请号：EP10765442.8
申请日：2010-10-14
发明人： PRIEPKE, Henning , DOODS, Henri , KUELZER, Raimund , PFAU, Roland , STENKAMP, Dirk , ROENN, Robert , PELCMAN, Benjamin
IPC分类号： C07C233/76 , C07C311/14 , C07D213/81 , C07D213/82 , C07D333/38 , C07D295/155 , A61P19/02 , A61P29/00 , A61P11/06 , A61K31/167 , A61K31/381 , A61K31/44 , A61K31/445
CPC分类号： C07D213/82 , C07C237/42 , C07C237/44 , C07C255/23 , C07C255/60 , C07C311/14 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/10 , C07D207/22 , C07D207/34 , C07D209/08 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/38 , C07D213/40 , C07D213/75 , C07D213/81 , C07D215/42 , C07D237/30 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D295/15 , C07D295/155 , C07D307/20 , C07D307/24 , C07D309/12 , C07D309/14 , C07D333/38 , C07D335/02 , C07D417/04
摘要： This invention relates to compounds of formula I, their use as inhibitors of the microsomal prostaglandin E
2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions such as inflammatory/nociceptive pain. A, M, R
1 , R
2 , R
7 ' R
a , R
b , Q
3 , Q
4 , Q
6 , Z
2 , Z
4 , Z
5 , Z
6 and W have meanings given in the description.-
6.发明授权2-ANILINOBENZIMIDAZOLE-6-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS 有权2- anilinobenzimidazole -6-羧酰胺作为抗炎剂
公开(公告)号：EP2606036B1
公开(公告)日：2014-10-08
申请号：EP11746237.4
申请日：2011-08-19
发明人： PRIEPKE, Henning , DOODS, Henri , KUELZER, Raimund , PFAU, Roland , STENKAMP, Dirk , PELCMAN, Benjamin , ROENN, Robert
IPC分类号： C07D235/30 , C07D403/12 , C07C271/20 , C07D401/12 , C07C211/52 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07C331/28 , C07C233/36 , C07C233/62 , C07D277/56 , C07D277/82 , A61P11/00 , A61P29/00
CPC分类号： C07D235/30 , C07C211/29 , C07C211/52 , C07C233/36 , C07C233/62 , C07C271/20 , C07C331/28 , C07C2601/02 , C07D277/56 , C07D277/82 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
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公开(公告)号：EP2606036A1
公开(公告)日：2013-06-26
申请号：EP11746237.4
申请日：2011-08-19
发明人： PRIEPKE, Henning , DOODS, Henri , KUELZER, Raimund , PFAU, Roland , STENKAMP, Dirk , PELCMAN, Benjamin , ROENN, Robert
IPC分类号： C07D235/30 , A61K31/4184 , A61P11/00 , A61P29/00
CPC分类号： C07D235/30 , C07C211/29 , C07C211/52 , C07C233/36 , C07C233/62 , C07C271/20 , C07C331/28 , C07C2601/02 , C07D277/56 , C07D277/82 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R6, R7, R8 have meanings given in the description.
摘要翻译： 本发明涉及式I化合物，其用作微粒体前列腺素E2合成酶-1（mPGES-1）的抑制剂，含有它们的药物组合物及其作为用于治疗和/或预防炎性疾病及相关病症的药物的用途。 A，M，W，R 1，R 2，R 6，R 7，R 8具有说明书中给出的含义。
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公开(公告)号：EP2403852B1
公开(公告)日：2014-10-29
申请号：EP10706659.9
申请日：2010-03-05
发明人： PFAU, Roland , ARNDT, Kirsten , DOODS, Henri , KLINDER, Klaus , KUELZER, Raimund , LUBRIKS, Dimitrijs , MACK, Juergen , PELCMAN, Benjamin , PRIEPKE, Henning , ROENN, Robert , STENKAMP, Dirk , SUNA, Edgars
IPC分类号： C07D235/30 , C07D401/12 , C07D405/12 , C07D409/12 , C07D403/12
CPC分类号： C07D235/30 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
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9.发明公开
公开(公告)号：EP2649071A1
公开(公告)日：2013-10-16
申请号：EP11791594.2
申请日：2011-12-09
发明人： PRIEPKE, Henning , DOODS, Henri , KUELZER, Raimund , PFAU, Roland , STENKAMP, Dirk , PELCMAN, Benjamin , ROENN, Robert , LUBRIKS, Dimitrijs , SUNA, Edgars
IPC分类号： C07D471/04 , A61K31/4188 , A61P29/00
CPC分类号： C07D471/04
摘要： This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E
2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, L, M, W, R
1 , R
2 , R
3 , R
4 , R
6 , R
7 , R
a , R
b have meanings given in the description.-
10.发明公开
公开(公告)号：EP2649052A1
公开(公告)日：2013-10-16
申请号：EP11796671.3
申请日：2011-12-09
发明人： PRIEPKE, Henning , KUELZER, Raimund , MACK, Juergen , PFAU, Roland , STENKAMP, Dirk , PELCMAN, Benjamin , ROENN, Robert , LUBRIKS, Dimitrijs , SUNA, Edgars
IPC分类号： C07D235/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , A61K31/4184 , A61P29/00
CPC分类号： C07D403/04 , C07D235/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： This invention relates to compounds of formula (I), their use as inhibitors of the microsomal prostaglandin E
2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the 10 treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R
1 , R
2 , R
3 , R
4 , R
6 , R
2 ,R
7 , R
8 , R
9 , R
a , R
b have meanings given in the description.
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