发明公开
- 专利标题： KINASE INHIBITORS
- 专利标题（中）： 激酶抑制剂
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申请号： EP10827573.6申请日： 2010-10-29
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公开(公告)号： EP2493313A1公开(公告)日： 2012-09-05
- 发明人: KIM, Hong, Woo , KOH, Jong, Sung , LEE, Jaekyoo , SONG, Ho-Juhn , KIM, Youngsam , LEE, Hee, Kyu , CHOI, Jang-Sik , LIM, Sun-Hee , CHANG, Sunhwa
- 申请人： Genosco , Oscotec Inc.
- 申请人地址： 12801 Busch Place Santa Fe Springs, CA 90670 US
- 专利权人： Genosco,Oscotec Inc.
- 当前专利权人： Genosco,Oscotec Inc.
- 当前专利权人地址： 12801 Busch Place Santa Fe Springs, CA 90670 US
- 代理机构： Hager, Thomas Johannes
- 优先权： US256222P 20091029
- 国际公布： WO2011053861 20110505
- 主分类号： A01N43/90
- IPC分类号： A01N43/90 ; A61K31/519
摘要：
The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,-
d ]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-
d ]pyrimidin-5-one derivatives.
d ]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-
d ]pyrimidin-5-one derivatives.
公开/授权文献
- EP2493313B1 KINASE INHIBITORS 公开/授权日：2017-12-13
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