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    KINASE INHIBITORS
    7.
    发明公开
    KINASE INHIBITORS 有权
    激酶INHIBITOREN

    公开(公告)号：EP2493313A4

    公开(公告)日：2013-05-15

    申请号：EP10827573

    申请日：2010-10-29

    申请人： GENOSCO ,  OSCOTEC INC

    发明人： KIM HONG WOO ,  KOH JONG SUNG ,  LEE JAEKYOO ,  SONG HO-JUHN ,  KIM YOUNGSAM ,  LEE HEE KYU ,  CHOI JANG-SIK ,  LIM SUN-HEE ,  CHANG SUNHWA

    IPC分类号： A61K31/519 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C07D471/04

    CPC分类号： A61K31/519 ,  C07D471/04

    摘要： The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,-d]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-d]pyrimidin-5-one derivatives.

    摘要翻译： 本发明提供了一组新的蛋白激酶抑制剂，吡啶并[4,3，-d]嘧啶-5-酮衍生物及其药学上可接受的盐，其可用于促进细胞增殖性疾病和病症如癌症，自身免疫性疾病， 感染，心血管疾病和神经变性疾病和障碍。 本发明提供了合成和施用蛋白激酶抑制剂化合物的方法。 本发明还提供了包含至少一种蛋白激酶抑制剂化合物以及药学上可接受的载体，稀释剂或赋形剂的药物制剂。 本发明还提供了在吡啶并[4,3， - d]嘧啶-5-酮衍生物的合成过程中产生的有用的中间体。

    KINASE INHIBITORS
    8.
    发明公开
    KINASE INHIBITORS 有权
    激酶抑制剂

    公开(公告)号：EP2498607A1

    公开(公告)日：2012-09-19

    申请号：EP10830814.9

    申请日：2010-11-12

    申请人： Genosco ,  Oscotec Inc.

    发明人： LEE, Jaekyoo ,  SONG, Ho-Juhn ,  KOH, Jong, Sung ,  LEE, Hee, Kyu ,  KIM, Youngsam ,  KIM, Hong, Woo ,  CHANG, Sunhwa ,  LIM, Sun-Hee ,  CHOI, Jang-Sik ,  KIM, Jung-Ho ,  KIM, Se-Won ,  KIM, Se-Won

    IPC分类号： A01N43/54 ,  A61K31/505

    CPC分类号： A61K31/505 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  C07D487/08

    摘要： The present invention provides a new group of protein kinase inhibitors, pyrropyrimidine and pyrazolopyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrropyrimidine and pyrazolopyrimidine derivatives.

    摘要翻译： 本发明提供了一组新的蛋白激酶抑制剂，吡咯嘧啶和吡唑并嘧啶衍生物及其药学上可接受的盐和前药，其可用于治疗细胞增殖性疾病和病症如癌症，自身免疫性疾病，感染，心血管疾病和神经变性疾病和病症 。 本发明提供了合成和施用蛋白激酶抑制剂化合物的方法。 本发明还提供了药物制剂，其包含至少一种蛋白激酶抑制剂化合物以及药学上可接受的载体，稀释剂或赋形剂。 本发明还提供了在合成pyrropyrimidine和吡唑并嘧啶衍生物期间产生的有用中间体。

    METHOD FOR PREPARATION OF THE SUPERSATURATED SOLUTION OF CALCIUM PHOSPHATE AND THE THIN FILM OF CALCIUM PHOSPHATE CRYSTAL BY USING THE SOLUTION
    10.
    发明公开
    METHOD FOR PREPARATION OF THE SUPERSATURATED SOLUTION OF CALCIUM PHOSPHATE AND THE THIN FILM OF CALCIUM PHOSPHATE CRYSTAL BY USING THE SOLUTION 有权
    一种用于生产过饱和钙磷酸盐溶液和薄膜磷酸钙晶体使用相同

    公开(公告)号：EP1129028A2

    公开(公告)日：2001-09-05

    申请号：EP99944894.7

    申请日：1999-09-15

    申请人： Oscotec Inc. ,  Kim, Hyun-Man

    发明人： KIM, Hyun-Man ,  KO, Jea-Seung ,  KIM, Yoon-Ji ,  PARK, Soo-Jin

    IPC分类号： C01B25/32 ,  C30B7/04

    CPC分类号： A61L27/32 ,  C01B25/32

    摘要： The present invention relates to a method for preparation of the supersaturated calcium and phosphate ions solution and a method for preparation of the thin film of calcium phosphate crystal on solid surface by using the said solution. Particularly, the lowered temperature and/or the use of suitable buffer system inhibit the nucleation of calcium phosphate in aqueous solution, and thereby highly supersaturated calcium and phosphate ions solution can be prepared. And the thin film of calcium phosphate crystal on solid surface can be prepared with rapidity and good quality of high reactivity and low crystallinity by using the said solution. Also the thin film of calcium phosphate crystal prepared according to the present invention has biocompatibility and can be applied as biomaterials.