发明公开
EP2499124A1 FLUORO-SUBSTITUTED 2-ARYL-3,5-DICYANO-4-INDAZOLYL-6-METHYL-1,4-DIHYDROPYRIDINES AND USES THEREOF
有权
FLUOR取代的2-芳基-3,5-二氰基-4-吲唑基-6-甲基-1,4-二氢吡啶及其用途
- 专利标题： FLUORO-SUBSTITUTED 2-ARYL-3,5-DICYANO-4-INDAZOLYL-6-METHYL-1,4-DIHYDROPYRIDINES AND USES THEREOF
- 专利标题（中）： FLUOR取代的2-芳基-3,5-二氰基-4-吲唑基-6-甲基-1,4-二氢吡啶及其用途
-
申请号： EP10775812.0申请日： 2010-11-08
-
公开(公告)号： EP2499124A1公开(公告)日： 2012-09-19
- 发明人: VAKALOPOULOS, Alexandros , MICHELS, Martin , ZIMMERMANN, Katja , TEUSCH, Nicole , LOBELL, Mario , ENGEL, Karen
- 申请人： Bayer Pharma Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 优先权： EP09175642 20091111
- 国际公布： WO2011069761 20110616
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D401/14 ; C07D413/14 ; A61K31/4439 ; A61P35/00
摘要：
The present invention relates to novel, fluoro-substituted 2-aryl-3,5-dicyano-4-(1
H -indazol-5-yl)-6- methyl-l,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly Cancer and other proliferative disorders.
H -indazol-5-yl)-6- methyl-l,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly Cancer and other proliferative disorders.
公开/授权文献
信息查询
