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1.发明公开FLUORO-SUBSTITUTED 2-ARYL-3,5-DICYANO-4-INDAZOLYL-6-METHYL-1,4-DIHYDROPYRIDINES AND USES THEREOF 有权FLUOR取代的2-芳基-3,5-二氰基-4-吲唑基-6-甲基-1,4-二氢吡啶及其用途
公开(公告)号：EP2499124A1
公开(公告)日：2012-09-19
申请号：EP10775812.0
申请日：2010-11-08
发明人： VAKALOPOULOS, Alexandros , MICHELS, Martin , ZIMMERMANN, Katja , TEUSCH, Nicole , LOBELL, Mario , ENGEL, Karen
IPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , A61K31/4439 , A61P35/00
CPC分类号： C07D413/14 , C07D401/04 , C07D401/14
摘要： The present invention relates to novel, fluoro-substituted 2-aryl-3,5-dicyano-4-(1
H -indazol-5-yl)-6- methyl-l,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly Cancer and other proliferative disorders.-
2.发明公开FLUORINATED 2,6-DIALKYL-3,5-DICYANO-4-(1H-INDAZOL-5-YL)-1,4-DIHYDROPYRIDINES AND METHODS OF USE THEREOF 有权氟化2,6-二烷基-3,5-二氰基-4-（1H-吲唑-5-基）-1,4-二氢吡啶及其使用THEREFOR方法
公开(公告)号：EP2493873A1
公开(公告)日：2012-09-05
申请号：EP10759927.6
申请日：2010-10-01
发明人： MICHELS, Martin , FOLLMANN, Markus , VAKALOPOULOS, Alexandros , ZIMMERMANN, Katja , TEUSCH, Nicole , LOBELL, Mario , ENGEL, Karen
IPC分类号： C07D401/04 , A61K31/416
CPC分类号： C07D401/04 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K9/4866
摘要： The present invention relates to novel fluorinated 2,6-dialkyl-3,5-dicyano-4-(1
H -indazol-5-yl)-1,4- dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met- mediated conditions, particularly cancer and other proliferative disorders.-
3.发明公开INDAZOLYL-SUBSTITUTED DIHYDROISOXA-ZOLOPYRIDINES AND METHODS OF USE THEREOF 有权吲-取代DIHYDROISOXA-ZOLOPYRIDINE及使用方法
公开(公告)号：EP2451817A1
公开(公告)日：2012-05-16
申请号：EP10730728.2
申请日：2010-07-07
发明人： MICHELS, Martin , FOLLMANN, Markus , VAKALOPOULOS, Alexandros , ZIMMERMANN, Katja , TEUSCH, Nicole , LOBELL, Mario
IPC分类号： C07D498/04 , A61K31/437 , A61P35/00
CPC分类号： C07D498/04 , A61K31/437
摘要： This invention relates to novel 4-(indazol-5-yl)-4,7-dihydroisoxazolo[5,4-b]pyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.
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4.发明公开BI- AND TRICYCLIC INDAZOLE-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND USES THEREOF 有权二和三环INDAZOLSUBSTITUIERTE 1,4-二氢吡啶衍生物及其应用
公开(公告)号：EP2398790A1
公开(公告)日：2011-12-28
申请号：EP10702634.6
申请日：2010-02-05
发明人： MICHELS, Martin , FOLLMANN, Markus , VAKALOPOULOS, Alexandros , ZIMMERMANN, Katja , LOBELL, Mario , TEUSCH, Nicole , YUAN, Shendong
IPC分类号： C07D401/04 , C07D471/04 , C07D491/048 , C07D491/052 , C07D491/147 , C07D491/153 , C07D495/04 , A61K31/4353 , A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/438 , A61K31/4427 , A61P35/00
CPC分类号： C07D491/048 , C07D401/04 , C07D471/04 , C07D491/052 , C07D491/147 , C07D491/153 , C07D495/04 , C07D498/14
摘要： This invention relates to novel bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.
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5.发明公开FLUORO-SUBSTITUTED 3,5-DICYANO-4-(1H-INDAZOL-5-YL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF 有权氟取代的3,5-二氰基-4-（1H-吲唑-5-基）-2,6-二甲基-1,4-二氢吡啶衍生物及其使用方法
公开(公告)号：EP2485726A1
公开(公告)日：2012-08-15
申请号：EP10760348.2
申请日：2010-10-01
发明人： MICHELS, Martin , FOLLMANN, Markus , VAKALOPOULOS, Alexandros , ZIMMERMANN, Katja , TEUSCH, Nicole , LOBELL, Mario , BIERER, Donald , ENGEL, Karen , KISSEL, Maria
IPC分类号： A61K31/416 , C07D401/04
CPC分类号： C07D401/04
摘要： The present invention relates to novel fluoro-substituted 3,5-dicyano-4-(1
H -indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.-
6.发明授权ANNELLATED 4-(INDAZOLYL)-1,4-DIHYDROPYRIDINE DERIVATIVES AS c-Met MEDIATORS 有权稠合的4-（吲唑基）-1,4-二氢吡啶ALS的c-Met-介质
公开(公告)号：EP2300482B1
公开(公告)日：2012-01-04
申请号：EP09761399.6
申请日：2009-05-29
发明人： MICHELS, Martin , FOLLMANN, Markus , VAKALOPOULOS , Alexandros , ZIMMERMANN, Katja , TEUSCH, Nicole , ENGEL, Karen
IPC分类号： C07D498/04 , A61K31/538 , A61P35/00
CPC分类号： C07D498/04
摘要： This invention relates to novel annellated 4-(indazolyl)-l,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.
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