- 专利标题： 1,4-BENZODIAZEPINE-2,5-DIONES AND RELATED COMPOUNDS WITH THERAPEUTIC PROPERTIES
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申请号： EP10831982.3申请日： 2010-11-03
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公开(公告)号： EP2501695B1公开(公告)日： 2018-08-29
- 发明人: GLICK, Gary D.
- 申请人： The Regents of The University of Michigan
- 申请人地址： 1600 Huron Parkway, 2nd Floor Ann Arbor, MI 48109-2590 US
- 专利权人： The Regents of The University of Michigan
- 当前专利权人： The Regents of The University of Michigan
- 当前专利权人地址： 1600 Huron Parkway, 2nd Floor Ann Arbor, MI 48109-2590 US
- 代理机构： Witte, Weller & Partner Patentanwälte mbB
- 优先权： US262017P 20091117
- 国际公布： WO2011062766 20110526
- 主分类号： C07D403/10
- IPC分类号： C07D403/10 ; C07D401/10 ; C07D471/04 ; C07D487/04 ; A61K31/5513 ; A61K31/437 ; A61P9/10 ; A61P9/12
摘要：
The present invention provides novel chemical compounds characterized as Rho kinase (ROCK) inhibitors, methods for their discovery, and their therapeutic, research, and diagnostic use. In particular, the present invention provides 1,4-benzodiazepine-2,5-dione compounds and related compounds having ROCK inhibitory activity, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with ROCK activity.
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