公开(公告)号：EP4378463A3

公开(公告)日：2024-10-23

申请号：EP24167722.8

申请日：2018-05-31

申请人： Xeris Pharmaceuticals, Inc.

发明人： PRESTRELSKI, Steven J. ,  SANDOVAL, Michael A. ,  SLOAT, Brian R.

IPC分类号： A61K9/00 ,  A61K47/14 ,  A61K47/16 ,  A61K47/20 ,  A61K47/22 ,  A61K9/08 ,  A61K31/5513 ,  A61K31/198 ,  A61K31/4045 ,  A61P25/08 ,  A61P25/14 ,  A61P25/22

摘要： Embodiments of the invention are directed to formulations that provide a solution to the problem of small molecule ( e . g ., diazepam) precipitation at the injection site when administered as a highly-concentrated formulation. In certain aspects the formulations include at least one surfactant in a non-aqueous formulation, which prevents small molecule precipitation and improves the bioavailability of the drug by enhancing absorption into the systemic circulation.

公开(公告)号：EP4426683A1

公开(公告)日：2024-09-11

申请号：EP22801350.4

申请日：2022-10-04

申请人： F. Hoffmann-La Roche AG

发明人： BARTELS, Bjoern ,  CECERE, Giuseppe ,  GOBBI, Luca ,  HERNANDEZ, Maria-Clemencia ,  HUMM, Roland ,  OLIVARES MORALES, Andrés Miguel ,  PATINY-ADAM, Angélique ,  RUNTZ-SCHMITT, Valerie ,  SCHNIDER, Christian

IPC分类号： C07D243/24 ,  C07D243/26 ,  C07D487/04 ,  A61P25/00 ,  A61K31/5513 ,  A61K31/5517

CPC分类号： C07D487/04 ,  C07D243/24 ,  C07D243/26 ,  A61P25/00

公开(公告)号：EP4389223A1

公开(公告)日：2024-06-26

申请号：EP22215045.0

申请日：2022-12-20

申请人： Universität Regensburg

发明人： The designation of the inventor has not yet been filed

IPC分类号： A61P35/00 ,  C07D413/14 ,  A61K31/422 ,  A61K31/496 ,  A61K31/506 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/5513

CPC分类号： C07D413/14 ,  A61P35/00

摘要： The present application relates to compounds of formula (I), which inhibit FLT3. The present application further relates to a composition, preferably pharmaceutical composition, comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof and comprising a pharmaceutically acceptable excipient and/or carrier. The present application also relates to a compound of formula (I) or composition thereof for use in medicine. The present application also relates to a compound of formula (I) or composition thereof for use in a method of preventing or treating cancer, preferably blood cancer, more preferably leukemia, even more preferably acute myeloid leukemia (AML). Furthermore, the present application relates to a method of preparing a compound of formula (I).

公开(公告)号：EP3938372B1

公开(公告)日：2023-10-25

申请号：EP20711857.1

申请日：2020-03-13

发明人： HOWARD, Philip Wilson ,  CAILLEAU, Thais

IPC分类号： C07D519/00 ,  A61P35/00 ,  A61K31/5513 ,  A61K47/68

公开(公告)号：EP4257133A1

公开(公告)日：2023-10-11

申请号：EP22305461.0

申请日：2022-04-05

申请人： Institut Pasteur

发明人： CHITNIS, Chaitanya ,  WAGNER, Matthias ,  SPERANDIO, Olivier ,  CHECA RUANO, Luis ,  TOUQUI, Lhousseine ,  GORGETTE, Olivier ,  HUON, Christèle ,  FORMAGLIO, Pauline ,  AMINO, Rogerio ,  ALAGANAN, Aditi

IPC分类号： A61K31/517 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5513 ,  A61P33/06 ,  A61K45/06

摘要： The present invention is in the field of therapeutic drugs to treat malaria. In particular, the invention provides oxo-azaheterocyclic derivatives for use in the treatment of malaria, for example drug-resistant malaria.

公开(公告)号：EP4236961A1

公开(公告)日：2023-09-06

申请号：EP21887749.6

申请日：2021-11-01

申请人： Emory University ,  Hadasit Medical Research Services&Development Ltd.

发明人： SCHINAZI, Raymond F. ,  COX, Bryan ,  GALUN, Eithan ,  AMBLARD, Franck ,  PATEL, Dharmeshkumar

IPC分类号： A61K31/5513 ,  A61K31/551 ,  A61K31/55 ,  A61P3/06 ,  A61P35/00

公开(公告)号：EP4203938A1

公开(公告)日：2023-07-05

申请号：EP21769366.2

申请日：2021-08-23

申请人： Université de Genève

发明人： ZANGARI, Joséphine ,  MARTINOU, Jean-Claude

IPC分类号： A61K31/198 ,  A61K31/53 ,  A61P35/00 ,  A61K31/5513 ,  A61P7/00 ,  A61P7/06

公开(公告)号：EP4132493A1

公开(公告)日：2023-02-15

申请号：EP21785304.3

申请日：2021-04-07

申请人： The Trustees of Indiana University

发明人： SEN, Chandan K. ,  ROY, Sashwati ,  EL MASRY, Mohamed ,  GOPALAKRISHNAN, Vinoj

IPC分类号： A61K31/137 ,  A61K31/5513 ,  A61K9/50

公开(公告)号：EP4114378A1

公开(公告)日：2023-01-11

申请号：EP21709415.0

申请日：2021-03-05

申请人： Université de Lausanne

发明人： BAGNI, Claudia ,  ACHSEL, Tilmann ,  KANELLOPOULOS, Alexandros

IPC分类号： A61K31/185 ,  A61K31/305 ,  A61K31/366 ,  A61K31/4745 ,  A61K31/5513 ,  A61K31/661 ,  A61P25/00 ,  A61P25/18 ,  G01N33/50 ,  G01N33/94

公开(公告)号：EP4085899A1

公开(公告)日：2022-11-09

申请号：EP22166182.0

申请日：2012-06-13

申请人： Neurelis, Inc.

发明人： CARTT, Steve ,  MEDEIROS, David ,  GWOZDZ, Garry Thomas ,  LOXLEY, Andrew ,  MITCHNICK, Mark ,  HALE, David ,  MAGGIO, Edward T.

IPC分类号： A61K9/08 ,  A61K47/10 ,  A61K47/22 ,  A61K47/26 ,  A61K31/5513 ,  A61P25/08

摘要： The invention relates to pharmaceutical compositions comprising one or more benzodiazepine drugs for nasal administration, methods for producing and for using such compositions.