发明公开
- 专利标题: ANTI-TUMOR EFFECT POTENTIATOR
- 专利标题(中): 潜伏者FÜR抗肿瘤剂WIRKUNGEN
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申请号: EP10833385.7申请日: 2010-11-29
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公开(公告)号: EP2508185A1公开(公告)日: 2012-10-10
- 发明人: FUKUOKA, Masayoshi , YOKOGAWA, Tatsushi , MIYAHARA, Seiji , MIYAKOSHI, Hitoshi , YANO, Wakako , TAGUCHI, Junko , TAKAO, Yayoi
- 申请人: Taiho Pharmaceutical Co., Ltd.
- 申请人地址: 1-27 Kandanishiki-cho Chiyoda-ku, Tokyo 1018444 JP
- 专利权人: Taiho Pharmaceutical Co., Ltd.
- 当前专利权人: Taiho Pharmaceutical Co., Ltd.
- 当前专利权人地址: 1-27 Kandanishiki-cho Chiyoda-ku, Tokyo 1018444 JP
- 代理机构: Blodig, Wolfgang
- 优先权: JP2009272738 20091130
- 国际公布: WO2011065541 20110603
- 主分类号: A61K31/513
- IPC分类号: A61K31/513 ; A61P35/00 ; A61P35/02 ; A61P43/00 ; C07D239/54 ; C07D405/12
摘要:
There is provided an agent for potentiating the effects of an anti-tumor agent.
An anti-tumor effect potentiator containing, as an active ingredient, a uracil compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof:
wherein X represents a C 1-5 alkylene group and one of methylene groups constituting the alkylene group is optionally substituted with an oxygen atom;
R 1 represents a hydrogen atom or a C 1-6 alkyl group; R 2 represents a hydrogen atom or a halogen atom; and R 3 represents a C 1-6 alkyl group, a C 2-6 alkenyl group, a C 3-6 cycloalkyl group, a (C 3-6 cycloalkyl) C 1-6 alkyl group, a halogeno-C 1-6 alkyl group or a saturated heterocyclic group.
An anti-tumor effect potentiator containing, as an active ingredient, a uracil compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof:
wherein X represents a C 1-5 alkylene group and one of methylene groups constituting the alkylene group is optionally substituted with an oxygen atom;
R 1 represents a hydrogen atom or a C 1-6 alkyl group; R 2 represents a hydrogen atom or a halogen atom; and R 3 represents a C 1-6 alkyl group, a C 2-6 alkenyl group, a C 3-6 cycloalkyl group, a (C 3-6 cycloalkyl) C 1-6 alkyl group, a halogeno-C 1-6 alkyl group or a saturated heterocyclic group.
公开/授权文献
- EP2508185B1 ANTI-TUMOR EFFECT POTENTIATOR 公开/授权日:2020-03-04
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