发明公开
- 专利标题： Uracyl Spirooxetane Nucleosides
- 专利标题（中）： 尿嘧啶 - spirooxetan-nukleoside
-
申请号： EP12176402.1申请日： 2010-05-11
-
公开(公告)号： EP2511282A1公开(公告)日： 2012-10-17
- 发明人: Jonckers, Tim Hugo Maria , Raboisson, Pierre Jean-Marie Bernard , Vandyck, Koen , Van Hoof, Steven Maurice Paula , Hu, Lili , Tahri, Abdellah
- 申请人： Janssen Products, L.P. , MEDIVIR AB
- 申请人地址： 800/850 Ridgeway Drive Horsham PA 19044 US
- 专利权人： Janssen Products, L.P.,MEDIVIR AB
- 当前专利权人： Janssen Products, L.P.,MEDIVIR AB
- 当前专利权人地址： 800/850 Ridgeway Drive Horsham PA 19044 US
- 代理机构： van Wanrooij, Eva
- 优先权： EP09160215 20090514
- 主分类号： C07H19/06
- IPC分类号： C07H19/06 ; C07H19/10 ; C07H19/067 ; A61K31/7072 ; C07D493/10 ; C07H15/18 ; C07H15/04 ; C07D201/00
摘要：
Compounds of the formula I:
including any possible stereoisomers thereof, wherein:
R 4
is a monophosphate, diphosphate or triphosphate ester; or R 4 is
R 7
is optionally substituted phenyl, optionally substituted naphthyl, or optionally substituted indolyl;
R 8 and R 8'
are hydrogen, C 1 -C 6 alkyl, benzyl, or phenyl; or R 8 and R 8' form C 3 -C 7 cycloalkyl;
R 9
is C 1 -C 10 alkyl, C 3 -C 7 cycloalkyl, phenyl or phenyl-C 1 -C 6 alkyl, wherein the phenyl moiety in phenyl or phenyl-C 1 -C 6 alkyl is optionally substituted;
or a pharmaceutically acceptable salt or solvate thereof;
pharmaceutical formulations and the use of compounds I as HCV inhibitors.
including any possible stereoisomers thereof, wherein:
R 4
is a monophosphate, diphosphate or triphosphate ester; or R 4 is
R 7
is optionally substituted phenyl, optionally substituted naphthyl, or optionally substituted indolyl;
R 8 and R 8'
are hydrogen, C 1 -C 6 alkyl, benzyl, or phenyl; or R 8 and R 8' form C 3 -C 7 cycloalkyl;
R 9
is C 1 -C 10 alkyl, C 3 -C 7 cycloalkyl, phenyl or phenyl-C 1 -C 6 alkyl, wherein the phenyl moiety in phenyl or phenyl-C 1 -C 6 alkyl is optionally substituted;
or a pharmaceutically acceptable salt or solvate thereof;
pharmaceutical formulations and the use of compounds I as HCV inhibitors.
公开/授权文献
- EP2511282B1 Uracyl Spirooxetane Nucleosides 公开/授权日：2014-04-02
信息查询
IPC分类:
