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1111 条记录 (耗时 0.019 秒)

    NUCLEOSIDE DERIVATIVE AND USE THEREOF
    9.
    发明公开
    NUCLEOSIDE DERIVATIVE AND USE THEREOF 审中-公开

    公开(公告)号：EP4052730A1

    公开(公告)日：2022-09-07

    申请号：EP20882572.9

    申请日：2020-10-28

    申请人： National University Corporation Tokai National Higher Education and Research System ,  YAMASA CORPORATION

    发明人： UENO,Yoshihito

    IPC分类号： A61K48/00 ,  C07H19/10 ,  C12N15/113 ,  A61K31/713

    摘要： Provided is a nucleoside derivative represented by the following formula (1):

    , or a salt thereof,
    wherein R 1 represents an alkoxy group, a hydrogen atom or a halogen atom; R 2 and R 4 , which may be the same as or different from each other, each represents a hydrogen atom, a protective group for a hydroxyl group, a phosphate group, a protected phosphate group, or -P(=O) n R 5 R 6 in which n represents 0 or 1, R 5 and R 6 , which may be the same as or different from each other, each represents a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a mercapto group, a protected mercapto group, an alkoxy group, a cyanoalkoxy group, an amino group, or a substituted amino group, provided that when n is 1, both R 5 and R 6 cannot be the hydrogen atom at the same time; R 3 represents -(CH 2 ) m NHR 7 in which m represents an integer of 1 to 6, R 7 represents a hydrogen atom, an alkyl group, an alkenyl group or a protective group for an amino group; and B represents a purin-9-yl group, a 2-oxo-pyrimidin-1-yl group, a substituted purin-9-yl group, or a substituted 2-oxo-pyrimidin-1-yl group.