公开(公告)号：EP4108671B1

公开(公告)日：2024-11-20

申请号：EP22173763.8

申请日：2011-10-03

Inventor： Schrum, Jason P ,  Siddiqi, Suhaib ,  Ejebe, Kenechi

IPC: C07H19/10 ,  C07H21/02 ,  C12N15/11 ,  A61K31/7115

公开(公告)号：EP4392431A1

公开(公告)日：2024-07-03

申请号：EP22793641.6

申请日：2022-09-29

Applicant: Pyrotech (Beijing) Biotechnology Co., Ltd.

Inventor： DU, Nana ,  O'YANG, Counde ,  WANG, Hexiang ,  LI, Zhihong

IPC: C07H19/10 ,  C07H19/207 ,  A61K31/7052 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07H19/10 ,  C07H19/207 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07H13/02

公开(公告)号：EP3728592B1

公开(公告)日：2024-05-29

申请号：EP18833230.8

申请日：2018-12-21

IPC: C12N15/11 ,  C07F9/165 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00

CPC classification number: C07H21/00 ,  C12N15/111 ,  C12N2310/31320130101 ,  C12N2310/31520130101 ,  C12N2310/323120130101 ,  C12N2310/34620130101 ,  C07F9/65586 ,  C07F9/6561 ,  C07F9/65616 ,  C07H1/02

公开(公告)号：EP4303314A3

公开(公告)日：2024-04-17

申请号：EP23186456.2

申请日：2016-08-26

Applicant: F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

Inventor： BERGMANN, Frank ,  SEIDEL, Christoph ,  TRANS, Andrew ,  GREMYACHINSKIY, Dimitry ,  KUCHELMEISTER, Hannes ,  HILLRINGHAUS, Lars

IPC: C12Q1/6869 ,  C07H19/10 ,  C07H19/20

CPC classification number: C07H19/10 ,  C07H19/20 ,  C12Q1/6869

Abstract: The present disclosure relates to compositions and methods based on polypeptide-tagged nucleotide, and the use of such polypeptide-tagged nucleotides in nanopore devices and methods.

公开(公告)号：EP4347857A1

公开(公告)日：2024-04-10

申请号：EP22747154.7

申请日：2022-05-19

Applicant: ILLUMINA, INC. ,  Illumina Cambridge Limited

Inventor： SCHNEIDER, Kim ,  BETLEY, Jason ,  MILLER, Oliver ,  DREWS, Bradley ,  SMITH, Dominic ,  PANCHAPAKESAN, Rajagopal ,  MCCAULEY, Patrick ,  MASON, Stephen ,  MOSCHETTI, Tommaso ,  CHESNEY, Michael ,  RICHARDSON, Marta ,  LAWRENCE, Elliot ,  JACKSON, Amanda ,  JACKSON, Rosamond ,  IMSAND, Erin ,  DAY, Henry

IPC: C12P19/30 ,  C12N9/12 ,  C12Q1/6869 ,  C12P19/34 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/04

公开(公告)号：EP4282482A3

公开(公告)日：2024-01-17

申请号：EP23197008.8

申请日：2008-03-26

Applicant: Gilead Sciences, Inc.

Inventor： SOFIA, Michael, Joseph ,  DU, Jinfa ,  WANG, Peiyuan ,  NAGARATHNAM, Dhanapalan

IPC: C07H19/10 ,  A61K31/7072 ,  A61P31/00

Abstract: Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure:

Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.

公开(公告)号：EP4275690A3

公开(公告)日：2023-11-22

申请号：EP23191049.8

申请日：2019-11-11

Applicant: Mitsubishi Tanabe Pharma Corporation

Inventor： SAWAMOTO, Hiroaki ,  KUMAGAI, Shinji ,  FURUKAWA, Hiroyuki ,  ARAKI, Tomo ,  UTSUGI, Masayuki ,  OBIKA, Satoshi

IPC: C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/04 ,  A61P43/00 ,  C12N15/10 ,  A61K31/712

Abstract: The present invention provides a novel bridged artificial nucleic acid and an oligomer containing the same as a monomer. The present invention provides specifically a compound represented by general formula (I) (wherein each symbol is the same as defined in the specification) or salts thereof; as well as an oligonucleotide compound represented by general formula (I') (wherein each symbol is the same as defined in the specification) or salts thereof.

公开(公告)号：EP4028407B1

公开(公告)日：2023-08-16

申请号：EP20776287.3

申请日：2020-09-10

Inventor： MALYSHEV, Denis ,  FELDMAN, Aaron, W.

IPC: C07H19/00 ,  C07H21/00 ,  C07H1/00 ,  C07H19/10 ,  C07H19/20

公开(公告)号：EP4092118A1

公开(公告)日：2022-11-23

申请号：EP21215936.2

申请日：2018-12-21

Applicant: Roche Innovation Center Copenhagen A/S

Inventor： BLEICHER, Konrad ,  DUSCHMALÉ, Joerg ,  DUSCHMALÉ, Martina Brigitte ,  HANSEN, Henrik Frydenlund ,  KOCH, Troels ,  LI, Meiling ,  SCHAEUBLIN, Adrian ,  SHU, Xi ,  WU, Yong

IPC: C12N15/11 ,  C07F9/165 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00

Abstract: The present invention relates to a compound of formula (II) or (IIb)

wherein X, Y, R x , R y , R 5 and Nu are as defined in the description and in the claims. The compound of formula (II) can be used in the manufacture of oligonucleotides.

公开(公告)号：EP4052730A1

公开(公告)日：2022-09-07

申请号：EP20882572.9

申请日：2020-10-28

Applicant: National University Corporation Tokai National Higher Education and Research System ,  YAMASA CORPORATION

Inventor： UENO,Yoshihito

IPC: A61K48/00 ,  C07H19/10 ,  C12N15/113 ,  A61K31/713

Abstract: Provided is a nucleoside derivative represented by the following formula (1):

, or a salt thereof,
wherein R 1 represents an alkoxy group, a hydrogen atom or a halogen atom; R 2 and R 4 , which may be the same as or different from each other, each represents a hydrogen atom, a protective group for a hydroxyl group, a phosphate group, a protected phosphate group, or -P(=O) n R 5 R 6 in which n represents 0 or 1, R 5 and R 6 , which may be the same as or different from each other, each represents a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a mercapto group, a protected mercapto group, an alkoxy group, a cyanoalkoxy group, an amino group, or a substituted amino group, provided that when n is 1, both R 5 and R 6 cannot be the hydrogen atom at the same time; R 3 represents -(CH 2 ) m NHR 7 in which m represents an integer of 1 to 6, R 7 represents a hydrogen atom, an alkyl group, an alkenyl group or a protective group for an amino group; and B represents a purin-9-yl group, a 2-oxo-pyrimidin-1-yl group, a substituted purin-9-yl group, or a substituted 2-oxo-pyrimidin-1-yl group.