发明公开
EP2514749A1 OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY
有权
OXADIAZOLDERIVAT MIT ENDOTHELIALLIPASE-HEMMENDER WIRKUNG
- 专利标题: OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY
- 专利标题(中): OXADIAZOLDERIVAT MIT ENDOTHELIALLIPASE-HEMMENDER WIRKUNG
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申请号: EP10837586.6申请日: 2010-12-14
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公开(公告)号: EP2514749A1公开(公告)日: 2012-10-24
- 发明人: MASUDA, Koji , KIDA, Shiro , YOSHIKAWA, Naoki , KATOU, Manabu , KATO, Terukazu , NAKAJIMA, Mado , KOJIMA, Eiichi , YONEHARA, Mitsuhiro
- 申请人: Shionogi & Co., Ltd.
- 申请人地址: 1-8 Doshomachi 3-chome Chuo-ku Osaka-shi Osaka 541-0045 JP
- 专利权人: Shionogi & Co., Ltd.
- 当前专利权人: Shionogi & Co., Ltd.
- 当前专利权人地址: 1-8 Doshomachi 3-chome Chuo-ku Osaka-shi Osaka 541-0045 JP
- 代理机构: Webster, Jeremy Mark
- 优先权: JP2009283965 20091215; JP2010098009 20100421
- 国际公布: WO2011074560 20110623
- 主分类号: C07D413/06
- IPC分类号: C07D413/06 ; A61K31/4245 ; A61K31/428 ; A61K31/433 ; A61K31/437 ; A61K31/4439 ; A61K31/454 ; A61K31/5377 ; A61P3/04 ; A61P3/06 ; A61P3/10 ; A61P9/10 ; A61P43/00 ; C07D417/06 ; C07D417/14 ; C07D513/04
摘要:
Disclosed is a compound which is useful as an endothelial lipase inhibitor.
A compound represented by the formula:
its pharmaceutically acceptable salt, or a solvate thereof,
wherein
Ring A is aromatic carbocycle or aromatic heterocycle,
Z is -NR 5 -, -O- or -S-,
R 5 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl or the like,
R 1 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like,
R 2 and R 3 are each independently hydrogen, halogen, hydroxy or the like,
R 4 is a group represented by the formula: -(CR 6 R 7 )n-R 8 ,
wherein R 6 and R 7 are each independently hydrogen, halogen, hydroxy or the like, n is an integer of 0 to 3, R 8 is carboxy, cyano, substituted or unsubstituted alkyl or the like,
R x is halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like,
m is an integer of 0 to 3.
A compound represented by the formula:
its pharmaceutically acceptable salt, or a solvate thereof,
wherein
Ring A is aromatic carbocycle or aromatic heterocycle,
Z is -NR 5 -, -O- or -S-,
R 5 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl or the like,
R 1 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like,
R 2 and R 3 are each independently hydrogen, halogen, hydroxy or the like,
R 4 is a group represented by the formula: -(CR 6 R 7 )n-R 8 ,
wherein R 6 and R 7 are each independently hydrogen, halogen, hydroxy or the like, n is an integer of 0 to 3, R 8 is carboxy, cyano, substituted or unsubstituted alkyl or the like,
R x is halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like,
m is an integer of 0 to 3.
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