公开(公告)号：EP4499056A1

公开(公告)日：2025-02-05

申请号：EP23728596.0

申请日：2023-03-30

Applicant: Otto-von-Guericke-Universität Magdeburg

Inventor： LESSMANN, Volkmar ,  GOTTMANN, Kurt ,  ENDRES, Thomas ,  KARTALOU, Georgia-Ioanna

IPC: A61K31/137 ,  A61K31/397 ,  A61K31/4245 ,  A61K45/06 ,  A61P25/28

公开(公告)号：EP4442319A3

公开(公告)日：2025-01-15

申请号：EP24183456.3

申请日：2020-12-23

Applicant: Sitryx Therapeutics Limited

Inventor： COOKE, Michael Liam ,  COUSIN, David ,  FYFE, Matthew Colin Thor ,  WAUGH, Thomas Michael ,  AHMED, Salah ,  DE SIMONE, Alessio ,  TEOBALD, Barry John

IPC: C07D271/06 ,  A61K31/4245 ,  A61P19/02 ,  A61P29/00

Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response:

wherein

R A1 , R A2 , R C and R D are as defined herein.

公开(公告)号：EP3793999B1

公开(公告)日：2025-01-15

申请号：EP19804097.4

申请日：2019-05-17

Inventor： HUFF, Belinda ,  HOLLIS, Courtney ,  TOOP, Hamish ,  KUCHEL, Nathan ,  MITCHELL, Lorna Helen ,  SINGH, Rajinder ,  AVERY, Thomas ,  MICHAUT-SIMON, Celine ,  CONTRERAS, Jean-Marie ,  MORICE, Christophe

IPC: C07D471/04 ,  C07D231/14 ,  C07D213/81 ,  C07D213/82 ,  C07D239/28 ,  C07D239/34 ,  C07D241/24 ,  C07D249/10 ,  C07D271/10 ,  C07D277/56 ,  A61P29/00 ,  A61K31/4245 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/4965 ,  A61K31/519

公开(公告)号：EP4472954A1

公开(公告)日：2024-12-11

申请号：EP23753475.5

申请日：2023-02-10

Applicant: The University of North Carolina at Chapel Hill

Inventor： WANG, Xiaodong ,  ZHOU, Yubai

IPC: C07D261/20 ,  C07D413/04 ,  C07D413/14 ,  A61K31/423 ,  A61K31/4245 ,  A61P1/16 ,  A61P35/00 ,  A61P31/14 ,  A61P31/10 ,  A61P33/02

公开(公告)号：EP4446319A1

公开(公告)日：2024-10-16

申请号：EP23736981.4

申请日：2023-01-03

Applicant: Beijing Scitech-MQ Pharmaceuticals Limited

Inventor： ZHANG, Qiang ,  YANG, Leifu

IPC: C07D403/14 ,  A61K31/506 ,  A61K31/4245 ,  A61P35/00 ,  A61P37/00 ,  A61P17/00 ,  A61P1/00

Abstract: Provided are a carbonyl bridged heterocyclic compound having a structure represented by formula (I), a stereoisomer or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing these compounds, and an application of these compounds or composition in drug preparation. The compounds, the stereoisomer, the pharmaceutically acceptable salt thereof and the like can be used for treating or preventing autoimmune diseases, tumors and neurodegenerative diseases related to protein 1 kinase (RIPK1).

公开(公告)号：EP4438037A1

公开(公告)日：2024-10-02

申请号：EP24179001.3

申请日：2022-01-27

Applicant: Priothera SAS ,  Priothera Limited

Inventor： BUCHER, Christoph ,  DERTSCHNIG, Simone

IPC: A61K31/00 ,  A61K9/00 ,  A61K31/137 ,  A61K31/397 ,  A61K31/4245 ,  A61K31/426 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  A61K31/436 ,  A61K31/519 ,  A61K31/5377 ,  A61K38/13 ,  A61K31/13

CPC classification number: A61K31/137 ,  A61K31/00 ,  A61K31/397 ,  A61K31/4245 ,  A61K31/426 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  A61K31/5377 ,  A61K31/13 ,  A61K31/436 ,  A61K31/519

Abstract: The present invention relates to S1P receptor modulators, preferably mocravimod, for use in treating patients suffering from acute myelogenous leukemia (AML) and who have undergone allogeneic hematopoietic stem cell transplantation (HSCT). The invention relates in particular to methods of treating AML in subjects undergoing HSCT, wherein said method comprises daily administering an efficient amount of S1P receptor modulator, preferably mocravimod, to said subject in need thereof, for at least 6 months, preferably at least 12 months.

公开(公告)号：EP4415717A1

公开(公告)日：2024-08-21

申请号：EP22881955.3

申请日：2022-10-11

Applicant: Brown University ,  Rhode Island Hospital

Inventor： TAPINOS, Nikolaos ,  HASSAN, Ola ,  KARAMBIZI, David

IPC: A61K31/4709 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/47 ,  A61P35/00 ,  C07D271/02 ,  C07D271/06

CPC classification number: A61K31/41 ,  A61K31/4245 ,  A61K31/47 ,  A61K31/4709 ,  A61P35/00 ,  C07D271/06 ,  C07D413/04 ,  C07D413/14 ,  C07D498/10 ,  C07D413/06 ,  C07D413/10 ,  C07D471/04 ,  C07D519/00 ,  C07D403/04 ,  C07D487/04 ,  C07D491/052 ,  C07D413/12 ,  C07D417/12 ,  C07D417/04 ,  C07D403/10 ,  A61K31/713

公开(公告)号：EP4410286A1

公开(公告)日：2024-08-07

申请号：EP22875168.1

申请日：2022-09-30

Applicant: Shandong New Time Pharmaceutical Co., Ltd.

Inventor： ZHANG, Guimin ,  YAO, Jingchun ,  LI, Honghua ,  SUN, Chenghong ,  ZHAO, Tao

IPC: A61K31/4245 ,  A61K31/352 ,  A61P25/28 ,  A61K9/08 ,  A61K9/10 ,  A61K9/107 ,  A61K9/113 ,  A61K9/14 ,  A61K9/16 ,  A61K9/22 ,  A61K9/24 ,  A61K9/28 ,  A61K9/48

CPC classification number: A61K9/209 ,  A61K31/4245 ,  A61K9/107 ,  A61K9/20 ,  A61K9/10 ,  A61K9/14 ,  A61K9/48 ,  A61K9/16 ,  A61K9/28 ,  A61K9/08 ,  A61K9/113 ,  A61P25/28 ,  A61K31/352

Abstract: A pharmaceutical composition for preventing or treating Alzheimer's disease and use thereof are disclosed and belong to the technical field of medicines. The pharmaceutical composition includes
(Z)-3-(N-(3-bromo-4-fluorophenyl)-N'-hydroxyformamido)-4-(2-guanidinoethyl)amino)-1,2, 5-oxadiazole and anhydroicaritin. A pharmacodynamic experiment proves that the pharmaceutical composition achieves a synergistic therapeutic effect on treating Alzheimer's disease.

公开(公告)号：EP4395781A1

公开(公告)日：2024-07-10

申请号：EP22863742.7

申请日：2022-08-30

Applicant: Chong Kun Dang Pharmaceutical Corp.

Inventor： HA, Nina ,  BAE, Daekwon ,  KIM, Min Cheol ,  SONG, Ju Young ,  SUH, Dong-hyeon ,  LEE, Suk Jin ,  BAEK, Jiyeon ,  PARK, Jin Sol

IPC: A61K31/5377 ,  A61K31/496 ,  A61K31/4245 ,  A61K31/454 ,  A61K31/541 ,  A61P25/02 ,  C07D271/10 ,  C07D413/12 ,  C07D471/10 ,  C07D491/107

CPC classification number: A61K31/4245 ,  A61K31/438 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551 ,  A61P25/00 ,  A61P25/02 ,  C07D271/10 ,  C07D413/12 ,  C07D471/10 ,  C07D491/107 ,  A61K31/351 ,  A61K31/4523 ,  C07D413/04 ,  C07D413/14 ,  C07D417/12

公开(公告)号：EP4157834B1

公开(公告)日：2024-07-03

申请号：EP21732200.7

申请日：2021-05-27

IPC: C07D413/12 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/4025 ,  A61P35/00 ,  A61P25/00 ,  A61P25/28 ,  A61P3/00 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00

CPC classification number: C07D413/12 ,  A61P35/00 ,  A61P11/00 ,  A61P25/00 ,  A61P25/28 ,  A61P3/00 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10