发明公开
EP2519644A1 METHODS FOR DIAGNOSING THE MALIGNANT POTENTIAL OF PANCREATIC CYSTIC LESIONS
审中-公开
方法的诊断胰腺囊性病变的恶性潜能
- 专利标题： METHODS FOR DIAGNOSING THE MALIGNANT POTENTIAL OF PANCREATIC CYSTIC LESIONS
- 专利标题（中）： 方法的诊断胰腺囊性病变的恶性潜能
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申请号： EP10841730.4申请日： 2010-12-30
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公开(公告)号： EP2519644A1公开(公告)日： 2012-11-07
- 发明人: HAAB, Brian B. , SIMEONE, Diane
- 申请人： Van Andel Research Institute , The Regents of the University of Michigan
- 申请人地址： 333 Bostwick, N.E. Grand Rapids, MI 49503 US
- 专利权人： Van Andel Research Institute,The Regents of the University of Michigan
- 当前专利权人： Van Andel Research Institute,The Regents of the University of Michigan
- 当前专利权人地址： 333 Bostwick, N.E. Grand Rapids, MI 49503 US
- 代理机构： Wright, Simon Mark
- 优先权： US291654P 20091231
- 国际公布： WO2011082321 20110707
- 主分类号： C12Q1/00
- IPC分类号： C12Q1/00
摘要：
A method of diagnosing the malignant potential of a pancreatic cystic lesion in a subject including: detecting a glycan alteration in MUC5AC in a sample of pancreatic cystic lesion fluid from a subject, determining whether the glycan alteration is differentially present in the sample, and diagnosing the malignant potential of the pancreatic cystic lesion. A method of diagnosing the malignant potential of a pancreatic cystic lesion in a subject including: (a) detecting a glycan alteration in MUC5AC in a sample of pancreatic cystic lesion fluid from a subject, (b) detecting CA 19-9 in the sample, (c) determining whether the glycan alteration and CA 19-9 are differentially present in the sample, and (d) diagnosing the malignant potential of the pancreatic cystic lesion. Related methods of treatment and kits also are included.
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