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    Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
    1.
    发明公开
    Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use 有权
    甲状旁腺激素肽和甲状旁腺激素相关蛋白肽及使用方法

    公开(公告)号：EP2411038A2

    公开(公告)日：2012-02-01

    申请号：EP10756931.1

    申请日：2010-03-26

    申请人： Van Andel Research Institute ,  The General Hospital Corporation d/b/a Massachusetts General Hospital

    发明人： XU, Huaqiang Eric ,  PIOSZAK, Augen A. ,  GARDELLA, Thomas J.

    IPC分类号： A61K38/29

    CPC分类号： C07K14/635 ,  A61K38/00

    摘要： Provided herein are Parathyroid hormone (PTH) peptides and parathyroid hormone-related protein (PTHrP) peptides (e.g., PTH analogs, PTHrP analogs), and related variants, chemical derivatives, fusion polypeptides, multimeric polypeptides, and peptidomimetics, peptoids, the like. Also provided are their use in methods for activating the PTH receptor in a cell (e.g., an osteoblast), methods of treating a subject with bone loss (e.g., by administration of a PTH peptide or PTHrP peptide (e.g., a PTH analog or PTHrP analog)), methods of ameliorating a symptom associated with osteoporosis in a subject, methods of retarding the progression of osteoporosis in a subject, and methods of regenerating bone in a subject.

    摘要翻译： 本文提供了甲状旁腺激素（PTH）肽和甲状旁腺激素相关蛋白（PTHrP）肽（例如PTH类似物，PTHrP类似物）及相关变体，化学衍生物，融合多肽，多聚体多肽和肽模拟物，类肽等。 还提供了它们在用于激活细胞（例如成骨细胞）中的PTH受体的方法中的用途，治疗患有骨丢失的受试者的方法（例如通过施用PTH肽或PTHrP肽（例如，PTH类似物或PTHrP 类似物）），改善受试者中与骨质疏松症有关的症状的方法，延缓受试者中骨质疏松症进展的方法，以及再生受试者中的骨的方法。

    METHODS FOR MEASURING GLYCAN LEVELS OF PROTEINS
    3.
    发明公开
    METHODS FOR MEASURING GLYCAN LEVELS OF PROTEINS 审中-公开
    测量蛋白质甘氨酸水平的方法

    公开(公告)号：EP1877785A2

    公开(公告)日：2008-01-16

    申请号：EP06740875.7

    申请日：2006-04-12

    申请人： Van Andel Research Institute

    发明人： HAAB, Brian, Brummeler ,  CHEN, Songming

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6803 ,  G01N33/5308 ,  G01N33/57438

    摘要： The invention includes a high-through-put method of screening for a biomarker indicative of a disease, including the identification of a glycan alteration in a protein of a diseased patient. Further, the invention includes methods utilizing a microarray to measure the glycan level of a protein.

    摘要翻译： 本发明包括筛选指示疾病的生物标志物的高通量方法，包括鉴定患病患者的蛋白质中的聚糖改变。 此外，本发明包括利用微阵列来测量蛋白质的聚糖水平的方法。

    DOMAIN II MUTANTS OF ANTHRAX LETHAL FACTOR
    8.
    发明公开
    DOMAIN II MUTANTS OF ANTHRAX LETHAL FACTOR 审中-公开
    炭疽致死因子的结构域II突变体

    公开(公告)号：EP1809322A2

    公开(公告)日：2007-07-25

    申请号：EP05807509.4

    申请日：2005-10-03

    申请人： Van Andel Research Institute

    发明人： DUESBERY, Nicholas, S.

    IPC分类号： A61K39/07 ,  A61K39/00 ,  A61K39/02 ,  A61K38/00 ,  C07K1/00 ,  C07K2/00

    CPC分类号： C07K14/32 ,  A61K38/00 ,  A61K2039/53

    摘要： A series of mutants of Anthrax lethal factor (LF) are disclosed which define a conformational epitope or region of the molecule that interacts with the LF target, the MEK enzyme. Such mutants or variants, and nucleic acids encoding them are disclosed. The knowledge of such binding, separate from recognition of MEK by the protease active site of LF, serves as the basis for novel screening assays for discovery of inhibitors of this additional form of LF-MEK binding which is necessary for ultimate proteolysis and toxicity. The nontoxic LF mutants are useful as immunogenic compositions for generating antibodies and a state of immunity specific for the LF component of a B. anthracis infection or exposure otherwise to the anthrax lethal toxin.