发明公开
EP2526096A1 4-PHENOXY-NICOTINAMIDE OR 4-PHENOXY-PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS
有权
4-苯氧基 - 烟酰胺或4-苯氧基 - 嘧啶-4-甲酰胺
- 专利标题： 4-PHENOXY-NICOTINAMIDE OR 4-PHENOXY-PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS
- 专利标题（中）： 4-苯氧基 - 烟酰胺或4-苯氧基 - 嘧啶-4-甲酰胺
-
申请号： EP11700348.3申请日： 2011-01-18
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公开(公告)号： EP2526096A1公开(公告)日： 2012-11-28
- 发明人: BISSANTZ, Caterina , DEHMLOW, Henrietta , ERICKSON, Shawn, David , KIM, Kyungjin , MARTIN, Rainer, E. , OBST SANDER, Ulrike , PIETRANICO-COLE, Sherrie, Lynn , RICHTER, Hans , ULLMER, Christoph
- 申请人： F.Hoffmann-La Roche AG
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F.Hoffmann-La Roche AG
- 当前专利权人： F.Hoffmann-La Roche AG
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Klostermeyer-Rauber, Dörte
- 优先权： EP10151319 20100121
- 国际公布： WO2011089099 20110728
- 主分类号： C07D401/06
- IPC分类号： C07D401/06 ; C07D401/12 ; C07D401/14 ; C07D417/12 ; A61K31/44 ; A61K31/4427 ; A61K31/506 ; A61P3/00
摘要：
This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula (I), wherein A
1 , A
2 , B
1 , B
2 and R
1 to R
11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
1 , A
2 , B
1 , B
2 and R
1 to R
11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
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