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公开(公告)号：EP2861574B1
公开(公告)日：2016-04-20
申请号：EP13728748.8
申请日：2013-06-14
发明人： BUETTELMANN, Bernd , CECCARELLI, Simona M. , KUEHNE, Holger , KUHN, Bernd , NEIDHART, Werner , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07D333/66 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D495/04 , C07D495/10 , A61K31/381 , A61P3/10 , A61P35/00
CPC分类号： C07D417/04 , C07D333/50 , C07D333/66 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D495/04 , C07D495/10
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公开(公告)号：EP2888245A1
公开(公告)日：2015-07-01
申请号：EP13750576.4
申请日：2013-08-19
发明人： BUETTELMANN, Bernd , CONTE, Aurelia , KUEHNE, Holger , KUHN, Bernd , NEIDHART, Werner , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07D401/14 , C07D215/48 , C07D401/04 , C07D401/06 , C07D471/04 , A61K31/4353 , A61K31/47 , A61P3/10
CPC分类号： C07D491/052 , C07D215/54 , C07D221/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D495/04
摘要： The invention provides novel compounds having the general formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , R
9 , R
10 , R
11 , A
1 , A
2 , A
3 , m, n and p are as described herein, compositions including the compounds and methods of using the compounds.-
3.发明公开1-CYCLOALKYL- OR 1-HETEROCYCLYL-HYDROXYIMINO-3-PHENYL-PROPANES 审中-公开1-环烷基-2-甲基-1-环己基 - 羟基亚氨基-3-苯基丙酸
公开(公告)号：EP2771313A1
公开(公告)日：2014-09-03
申请号：EP12775028.9
申请日：2012-10-23
发明人： DEHMLOW, Henrietta , MARTIN, Rainer E. , MATTEI, Patrizio , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07C251/42 , C07C317/32 , C07D211/40 , C07D309/06 , C07D335/02 , A61K31/15 , A61K31/35 , A61K31/382 , A61K31/445 , A61K31/45 , A61P3/10
CPC分类号： C07D401/10 , C07C251/42 , C07C317/32 , C07C2601/04 , C07C2601/14 , C07D211/28 , C07D211/76 , C07D309/04 , C07D335/02
摘要： This invention relates to novel 1-cycloalkyl- or l-heterocyclyl-hydroxyimino-3-phen propanes of the formula wherein R
1 to R
7 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may therefore be useful as medicaments for the treatment of diseases such as type II diabetes.摘要翻译： 本发明涉及下式的新的1-环烷基 - 或1-杂环基 - 肟基-3-苯基 - 丙烷，其中R 1至R 7如说明书和权利要求书中所定义，以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂，因此可用作治疗诸如II型糖尿病的疾病的药物。
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公开(公告)号：EP2550254A1
公开(公告)日：2013-01-30
申请号：EP11711495.9
申请日：2011-03-21
发明人： BENSON, Gregory Martin , BLEICHER, Konrad , GRETHER, Uwe , KUHN, Bernd , RICHTER, Hans , TAYLOR, Sven
IPC分类号： C07D231/54 , C07D401/12 , C07D403/12 , A61K31/416 , A61K31/4439 , A61P3/04 , A61P3/06 , A61P3/10 , A61P25/16 , A61P25/28 , A61P35/00
CPC分类号： C07D231/54 , A61K9/0019 , A61K9/0095 , A61K9/1623 , A61K9/1652 , A61K9/2018 , A61K9/2866 , A61K9/4825 , A61K9/4858 , C07D401/12 , C07D403/12
摘要： This invention relates to novel cyclopentyl- and cycloheptylpyrazole derivatives of the formula (I) wherein A and R
1 to R
4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof, to compositions including these compounds and methods of using the compounds.摘要翻译： 本发明涉及式I的新的环戊基和环庚基吡唑衍生物，其中A和R 1至R 4如说明书和权利要求书中所定义，以及其生理上可接受的盐。 本发明还涉及包括这些化合物的组合物和使用该化合物的方法。
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公开(公告)号：EP1966199B1
公开(公告)日：2010-10-20
申请号：EP06829951.0
申请日：2006-11-08
IPC分类号： C07D471/04 , A61K31/4453 , A61K31/4462 , A61K31/4465 , A61P3/04 , A61P3/10
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein R1 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP1844026B1
公开(公告)日：2011-04-27
申请号：EP06700277.4
申请日：2006-01-10
发明人： BENTLEY, Jonathan, Mark , DAWSON, Claire, Elizabeth , GUBA, Wolfgang , HEBEISEN, Paul , MONCK, Nathaniel , PRATT, Robert, Mark , RICHTER, Hans , ROEVER, Stephan , RUSTON, Vicki
IPC分类号： C07D265/30 , A61K31/5375 , A61P3/04 , A61P3/10
CPC分类号： C07D265/30
摘要： The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in claim 1. These compounds can be used for the preparation of medicaments.
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公开(公告)号：EP1957479B1
公开(公告)日：2011-03-02
申请号：EP06830046.6
申请日：2006-11-20
发明人： NETTEKOVEN, Matthias , PLANCHER, Jean-Marc , RICHTER, Hans , ROCHE, Olivier , RUNTZ-SCHMITT, Valerie , TAYLOR, Sven
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , A61K31/4439 , A61P3/04
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
摘要： The present invention relates to compounds of formula (I) wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP1960401A1
公开(公告)日：2008-08-27
申请号：EP06819827.4
申请日：2006-11-29
IPC分类号： C07D487/04 , C07D471/14 , A61K31/4985 , A61P25/00 , A61P3/00 , A61P1/00
CPC分类号： C07D487/04 , C07D471/14
摘要： The present invention relates to compounds of formula (I) wherein A, G, r and R1 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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9.发明授权1,2-PYRIDAZINE, 1,6-PYRIDAZINE OR PYRIMIDINE-BENZAMIDE DERIVATIVES AS GPBAR1 MODULATORS 有权作为GPBAR1调节剂的1,2-哒嗪，1,6-哒嗪或嘧啶 - 苯甲酰胺衍生物
公开(公告)号：EP2834226B1
公开(公告)日：2016-05-25
申请号：EP13713197.5
申请日：2013-04-02
IPC分类号： C07D401/04 , A61K31/50 , A61K31/505 , C07D237/20 , C07D239/42 , A61P3/00 , A61P29/00
CPC分类号： C07D239/42 , C07D237/20 , C07D295/26 , C07D401/04
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10.发明授权1-PYRIDAZINYL-HYDROXYIMINO- 3- PHENYL- PROPANES AS GPBAR1 AGONISTS 有权1-吡啶基 - 羟基亚氨基-3-苯基 - 丙酸甲酯GPBAR1-AGONISTEN
公开(公告)号：EP2780330B1
公开(公告)日：2016-01-06
申请号：EP12784005.6
申请日：2012-11-12
发明人： DEHMLOW, Henrietta , MARTIN, Rainer E. , MATTEI, Patrizio , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07D237/08 , A61K31/50 , A61P3/10
CPC分类号： C07D237/08 , C07D237/14 , C07D401/10
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