发明公开
EP2532670A1 1, 4, 6, 10-TETRA-DOUBLE BOND PENTADEC-CARBON PHOSPHONATE, PREPARATION METHOD THEREOF, AND PREPARATION METHOD OF LYCOPENE USING SAME
有权
1,4,6,10四双重约束十五碳膦，工艺用于生产和方法番茄红素，成功年底投产
- 专利标题： 1, 4, 6, 10-TETRA-DOUBLE BOND PENTADEC-CARBON PHOSPHONATE, PREPARATION METHOD THEREOF, AND PREPARATION METHOD OF LYCOPENE USING SAME
- 专利标题（中）： 1,4,6,10四双重约束十五碳膦，工艺用于生产和方法番茄红素，成功年底投产
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申请号： EP11739331.4申请日： 2011-01-30
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公开(公告)号： EP2532670A1公开(公告)日： 2012-12-12
- 发明人: SHEN, Runpu , YE, Weidong , PI, Shiqing , LAO, Xuejun , LIU, Luo , SONG, Xiaohua , WU, Chunlei , WU, Zhigang
- 申请人： Shaoxing University , Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 申请人地址： No. 508 Huancheng Xilu Shaoxing, Zhejiang 312000 CN
- 专利权人： Shaoxing University,Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 当前专利权人： Shaoxing University,Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 当前专利权人地址： No. 508 Huancheng Xilu Shaoxing, Zhejiang 312000 CN
- 代理机构： De Anna, Pier Luigi
- 优先权： CN201010104281 20100202
- 国际公布： WO2011095052 20110811
- 主分类号： C07F9/40
- IPC分类号： C07F9/40 ; C07C11/21 ; C07C1/34
摘要：
1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4), and preparation method thereof are provided. The preparation method comprises: reacting a pseudo ionone of formula (2) with sulfonium salt to prepare a epoxide of formula (9), and then reacting the epoxide of formula (9) with magnesium bromide to prepare a C-14 aldehyde of formula (3); condensing the C-14 aldehyde of formula (3) with tetra-alkyl methylene diphosphonate to obtain 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4). Furthermore, the preparation method of lycopene via 1, 4, 6, 10-tetra-double bond pentadec-carbon phosphonate of formula (4) is also provided. The present method has the advantages of short route, easily obtained raw materials, and low cost.
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