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19 条记录 (耗时 0.014 秒)

    1, 4, 6, 10-TETRA-DOUBLE BOND PENTADEC-CARBON PHOSPHONATE, PREPARATION METHOD THEREOF, AND PREPARATION METHOD OF LYCOPENE USING SAME
    3.
    发明公开
    1, 4, 6, 10-TETRA-DOUBLE BOND PENTADEC-CARBON PHOSPHONATE, PREPARATION METHOD THEREOF, AND PREPARATION METHOD OF LYCOPENE USING SAME 有权
    1,4,6,10四双重约束十五碳膦，工艺用于生产和方法番茄红素，成功年底投产

    公开(公告)号：EP2532670A1

    公开(公告)日：2012-12-12

    申请号：EP11739331.4

    申请日：2011-01-30

    申请人： Shaoxing University ,  Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory

    发明人： SHEN, Runpu ,  YE, Weidong ,  PI, Shiqing ,  LAO, Xuejun ,  LIU, Luo ,  SONG, Xiaohua ,  WU, Chunlei ,  WU, Zhigang

    IPC分类号： C07F9/40 ,  C07C11/21 ,  C07C1/34

    CPC分类号： C07F9/4015 ,  C07C1/34 ,  C07C11/21

    摘要： 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4), and preparation method thereof are provided. The preparation method comprises: reacting a pseudo ionone of formula (2) with sulfonium salt to prepare a epoxide of formula (9), and then reacting the epoxide of formula (9) with magnesium bromide to prepare a C-14 aldehyde of formula (3); condensing the C-14 aldehyde of formula (3) with tetra-alkyl methylene diphosphonate to obtain 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4). Furthermore, the preparation method of lycopene via 1, 4, 6, 10-tetra-double bond pentadec-carbon phosphonate of formula (4) is also provided. The present method has the advantages of short route, easily obtained raw materials, and low cost.

    摘要翻译： 1,4,6,10四双键十五羧酸式（4），及其制备方法的膦酸盐中提供它们。 其制备方法包括：使式伪紫罗兰酮（2）与锍盐，以制备式（9），然后使式环氧化物的环氧化物（9）与溴化镁，制备下式的C-14醛（ 3）; 与四烷基甲基二膦缩合式（3）的C-14醛，得到1,4,6,10四双键十五羧酸式的膦酸盐（4）。 进一步，通过番茄红素的制备方法1，4,6，10-四双键十五羧酸式的膦酸盐（4）因此提供。 本发明的方法具有短路线，原料易得，成本低的优点。

    1-METHOXYL-2,6,10-TRIMETHYL-1,3,5,9-UNDEC-TETRAENE AND PREPARATION METHOD AND USES THEREOF
    8.
    发明公开
    1-METHOXYL-2,6,10-TRIMETHYL-1,3,5,9-UNDEC-TETRAENE AND PREPARATION METHOD AND USES THEREOF 有权
    1-甲氧基-2,6,10-三甲基-1,3,5,9-二十二碳三烯酸酯维生素ZU SEINER HERSTELLUNG UND VERWENDUNG

    公开(公告)号：EP2546226A1

    公开(公告)日：2013-01-16

    申请号：EP11765048.1

    申请日：2011-04-06

    申请人： University Of Shaoxing ,  ZheJiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory

    发明人： SHEN, Runpu ,  LAO, Xuejun ,  YE, Weidong ,  SONG, Xiaohua ,  WU, Chunlei ,  SUN, Xiongsheng ,  LIU, Luo ,  HU, Siping

    IPC分类号： C07C43/16 ,  C07C41/30 ,  C07C47/21 ,  C07C45/42

    CPC分类号： C07C43/16 ,  C07C41/30 ,  C07C45/42 ,  C07C47/21

    摘要： The invention discloses an intermediate 1-methoxyl-2, 6, 10-trimethyl-1, 3, 5, 9-undec-tetraene, and a preparation method and uses thereof. In the synthesis method for the current lycopene intermediate 2-pos double bond C-14 aldehyde (2, 6, 10-trimethyl-2, 5, 9-undecatriene-1-aldehyde), expensive methyl iodide, polluting dimethyl sulphide and dangerous strong base are needed, so that the method is hardly applied to industrial production. The invention provides a new compound 1-methoxyl-2, 6, 10-trimethyl-1, 3, 5, 9-undec-tetraene, and pure 2-pos double bond C-14 aldehyde can be prepared by hydrolyzing and refining the compound. The synthetic route is simplified and the great suitability for industrial production is achieved.

    摘要翻译： 本发明公开了中间体1-甲氧基-2,6,10-三甲基-1,3,5,9-十一四烯及其制备方法和用途。 在目前番茄红素中间体2-pos双键C-14醛（2,6,10-三甲基-2,5,9-十一碳烯-1-醛）的合成方法中，昂贵的甲基碘，污染二甲基硫化物和危险的强 需要这种方法，这种方法几乎不适用于工业生产。 本发明提供了一种新的化合物1-甲氧基-2,6,10-三甲基-1,3,5,9-十一四烯和纯的2-位双键C-14醛可以通过水解和精制化合物 。 合成路线简化，实现了工业生产的良好适应性。

    SEPARATION AND PURIFICATION METHOD FOR VANCOMYCIN HYDROCHLORIDE OF HIGH PURITY
    9.
    发明公开
    SEPARATION AND PURIFICATION METHOD FOR VANCOMYCIN HYDROCHLORIDE OF HIGH PURITY 审中-公开
    TRENNUNG UND VERFAHREN ZUR REINIGUNG VON HOCHREINEM VANCOMYCIN HYDROCHLORID

    公开(公告)号：EP3064214A1

    公开(公告)日：2016-09-07

    申请号：EP14857463.5

    申请日：2014-10-27

    申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory

    发明人： LI, Enmin ,  ZHUANG, Yiyun ,  WANG, Jue ,  SUN, Xinqiang ,  LAO, Xuejun ,  JIANG, Biwang

    IPC分类号： A61K38/14 ,  C07K9/00 ,  C07K1/22

    CPC分类号： C07K1/36 ,  A61K38/14 ,  C07K1/20 ,  C07K1/34 ,  C07K9/008

    摘要： Provided is a separation and purification method for vancomycin hydrochloride of high purity. The method comprises the following steps: (1) obtaining a vancomycin hydrochloride solution from a crude vancomycin product by ion exchange chromatography and obtaining a concentrate by nanofiltration desalination and concentration; (2) adjusting the concentrate with a hydrochloric acid solution and then performing a column chromatography using a reverse chromatography column for the adjusted concentrate; (3) collecting the chromatographic solution of vancomycin to obtain a mixed chromatographic solution; (4) adjusting the mixed chromatographic solution, and separating the solution and the salts by nanofiltration desalination and concentration to obtain a concentrate; and (5) obtaining a vancomycin dry powder with a chromatographic purity of up to 99% and a pure white appearance by dehydrating and drying the concentrate of step (4), or by solvent crystallization or salting-out crystallization.

    摘要翻译： 本发明提供了高纯度盐酸万古霉素的分离纯化方法。 该方法包括以下步骤：（1）通过离子交换色谱法从粗万古霉素产品中获得盐酸万古霉素溶液，并通过纳滤脱盐浓缩获得浓缩物; （2）用盐酸溶液调节浓缩物，然后使用反相色谱柱进行柱色谱用于调整浓缩物; （3）收集万古霉素的色谱溶液，得到混合色谱溶液; （4）调整混合色谱溶液，并通过纳滤脱盐浓缩分离溶液和盐，得到浓缩物; 和（5）通过使步骤（4）的浓缩物脱水干燥，或通过溶剂结晶或盐析结晶获得色谱纯度高达99％的纯净白色外观的万古霉素干粉。