发明公开
EP2542256A2 ANTIBODIES REACTIVE WITH B7-H3, IMMUNOLOGICALLY ACTIVE FRAGMENTS THEREOF AND USES THEREOF
审中-公开
与B7-H3反应性抗体，免疫署理其片段及其用途
- 专利标题： ANTIBODIES REACTIVE WITH B7-H3, IMMUNOLOGICALLY ACTIVE FRAGMENTS THEREOF AND USES THEREOF
- 专利标题（中）： 与B7-H3反应性抗体，免疫署理其片段及其用途
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申请号： EP11751204.6申请日： 2011-03-01
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公开(公告)号： EP2542256A2公开(公告)日： 2013-01-09
- 发明人: LOO, Deryk, T. , HUANG, Ling , CHEN, Francine Zhifen , MOORE, Paul A. , JOHNSON, Leslie S.
- 申请人： MacroGenics, Inc.
- 申请人地址： 9640 Medical Center Drive Rockville, MD 20850 US
- 专利权人： MacroGenics, Inc.
- 当前专利权人： MacroGenics, Inc.
- 当前专利权人地址： 9640 Medical Center Drive Rockville, MD 20850 US
- 代理机构： Broughton, Jon Philip
- 优先权： US310692P 20100304; US311057P 20100305; US310695P 20100304
- 国际公布： WO2011109400 20110909
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C07K16/00
摘要：
The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
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