利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

45 条记录 (耗时 0.063 秒)

    CD3-BINDING MOLECULES CAPABLE OF BINDING TO HUMAN AND NON-HUMAN CD3
    1.
    发明公开
    CD3-BINDING MOLECULES CAPABLE OF BINDING TO HUMAN AND NON-HUMAN CD3 审中-公开

    公开(公告)号：EP3492494A1

    公开(公告)日：2019-06-05

    申请号：EP18215748.7

    申请日：2012-05-16

    申请人： MacroGenics, Inc.

    发明人： HUANG, Ling ,  JOHNSON, Leslie, S.

    IPC分类号： C07K16/00

    摘要： The present invention relates to CD3 -binding molecules capable of binding to human and non-human CD3, and in particular to such molecules that are cross-reactive with CD3 of a non-human mammal (e.g., a cynomolgus monkey). The invention also pertains to uses of such antibodies and antigen-binding fragments in the treatment of cancer, autoimmune and/or inflammatory diseases and other conditions.

    T-CELL RECEPTOR ANTIBODIES AND METHODS OF USE THEREOF
    5.
    发明公开
    T-CELL RECEPTOR ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
    T细胞受体抗体和使用方法

    公开(公告)号：EP2328934A1

    公开(公告)日：2011-06-08

    申请号：EP09812010.8

    申请日：2009-08-25

    申请人： MacroGenics, Inc.

    发明人： BONVINI, Ezio ,  JOHNSON, Leslie, S. ,  TUAILLON, Nadine ,  HUANG, Ling

    IPC分类号： C07K16/28 ,  A61K39/395

    CPC分类号： C07K16/2809 ,  A61K2039/505 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/71

    摘要： The present invention is directed to the production and use of monoclonal antibodies, or antigen binding fragments thereof, that specifically bind the T cell antigen receptor (TCR) and their use for immunomodulation. In preferred embodiments, the antibody or antigen binding fragment of the invention specifically binds the constant region of the alpha chain of the TCR, or otherwise specifically binds the alpha chain regardless of TCR clonal origin (i.e., is pan specific for TCR). The antibodies of the invention may be used, for example, in immunosuppressive therapies for transplant maintenance and the treatment of autoimmune diseases, and/or as targeting molecules for use in the treatment of T-cell malignancies.

    COVALENT DIABODIES AND USES THEREOF
    9.
    发明公开
    COVALENT DIABODIES AND USES THEREOF 审中-公开

    公开(公告)号：EP3479844A1

    公开(公告)日：2019-05-08

    申请号：EP18191562.0

    申请日：2006-04-17

    申请人： MacroGenics, Inc.

    发明人： JOHNSON, Leslie S. ,  HUANG, Ling

    IPC分类号： A61K39/395 ,  C12P21/04 ,  C12P21/08 ,  C07K16/00 ,  C07H21/04 ,  C07K16/28 ,  C07K16/08 ,  C07K16/12 ,  C07K16/30 ,  C07K16/44

    摘要： The present invention is directed to diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers. The diabody molecules of the invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on the same or differing antigens. Additionally, the antigens may be from the same or different molecules. The individual polypeptide chains of the diabody molecule may be covalently bound through non-peptide bond covalent bonds, such as, but not limited to, disulfide bonding of cysteine residues located within each polypeptide chain. In particular embodiments, the diabody molecules of the present invention further comprise an Fc region, which allows antibody-like functionality to engineered into the molecule.

    COVALENT DIABODIES AND USES THEREOF
    10.
    发明公开
    COVALENT DIABODIES AND USES THEREOF 审中-公开

    公开(公告)号：EP3424951A1

    公开(公告)日：2019-01-09

    申请号：EP18187567.5

    申请日：2008-06-13

    申请人： MacroGenics, Inc.

    发明人： JOHNSON, Leslie S. ,  HUANG, Ling

    IPC分类号： C07K16/00 ,  C12P21/08 ,  C07K16/28 ,  C07K16/46

    摘要： The present invention is directed to diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers. The diabody molecules of the invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on the same or differing antigens. Additionally, the antigens may be from the same or different molecules. The individual polypeptide chains of the diabody molecule may be covalently bound through non- peptide bond covalent bonds, such as, but not limited to, disulfide bonding of cysteine residues located within each polypeptide chain. In particular embodiments, the diabody molecules of the present invention further comprise an Fc region, which allows antibody- like functionality to engineered into the molecule.