发明公开
EP2551272A1 LYCOPENE INTERMEDIATE 1, 3, 6, 10-TETRA-DOUBLE BOND PENTADEC-PHOSPHONATE, PREPARATION METHOD AND APPLICATION THEREOF
有权
番茄红素中间体1,3,6-,10-四 - 双键十五碳磷酸酯及其制备方法和应用
- 专利标题： LYCOPENE INTERMEDIATE 1, 3, 6, 10-TETRA-DOUBLE BOND PENTADEC-PHOSPHONATE, PREPARATION METHOD AND APPLICATION THEREOF
- 专利标题（中）： 番茄红素中间体1,3,6-,10-四 - 双键十五碳磷酸酯及其制备方法和应用
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申请号： EP11752834.9申请日： 2011-03-09
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公开(公告)号： EP2551272A1公开(公告)日： 2013-01-30
- 发明人: SHEN, Runpu , YE, Weidong , LAO, Xuejun , SONG, Xiaohua , LIU, Luo , WU, Chunlei , WU, Yibin , HU, Liujiang
- 申请人： ZheJiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory , University Of Shaoxing
- 申请人地址： No. 59 East Huancheng Rd. Xinchang Zhejiang 312500 CN
- 专利权人： ZheJiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory,University Of Shaoxing
- 当前专利权人： ZheJiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory,University Of Shaoxing
- 当前专利权人地址： No. 59 East Huancheng Rd. Xinchang Zhejiang 312500 CN
- 代理机构： Schmid, Klaus Michael Johannes
- 优先权： CN201010120583 20100309
- 国际公布： WO2011110091 20110915
- 主分类号： C07F9/40
- IPC分类号： C07F9/40 ; C07C11/21 ; C07C1/34
摘要：
The invention relates to a novel important lycopene intermediate 3, 7, 11-trimethyl-1, 3, 6, 10-tetraene-dodecyl diethyl phosphonate. A current lycopene intermediate 2, 4, 6, 10-tetra-double bond pentadec-carbon phosphonate is difficult to synthesize. The invention provides a novel intermediate, which has the following synthesis steps of: preparing 2, 6, 10-trimethyl-3, 5, 9-undecane triene-1-aldehyde from pseudoionone; preparing 2, 6, 10-trimethyl-2, 5, 9-undecane triene-1-aldehyde from the 2, 6, 10-trimethyl-3, 5, 9-undecane triene-1-aldehyde; and subjecting the 2, 6, 10-trimethyl-2, 5, 9-undecane triene-1-aldehyde and tetraethyl methylenediphosphonate to condensation reaction to obtain target product. The invention can generate novel intermediate from raw material pseudoionone only by four reactions, thus the reactions are easy to control and great industrial value are achieved.
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