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    LYCOPENE INTERMEDIATE 1, 3, 6, 10-TETRA-DOUBLE BOND PENTADEC-PHOSPHONATE, PREPARATION METHOD AND APPLICATION THEREOF
    1.
    发明公开
    LYCOPENE INTERMEDIATE 1, 3, 6, 10-TETRA-DOUBLE BOND PENTADEC-PHOSPHONATE, PREPARATION METHOD AND APPLICATION THEREOF 有权
    番茄红素中间体1,3,6-,10-四 - 双键十五碳磷酸酯及其制备方法和应用

    公开(公告)号：EP2551272A1

    公开(公告)日：2013-01-30

    申请号：EP11752834.9

    申请日：2011-03-09

    申请人： ZheJiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory ,  University Of Shaoxing

    发明人： SHEN, Runpu ,  YE, Weidong ,  LAO, Xuejun ,  SONG, Xiaohua ,  LIU, Luo ,  WU, Chunlei ,  WU, Yibin ,  HU, Liujiang

    IPC分类号： C07F9/40 ,  C07C11/21 ,  C07C1/34

    CPC分类号： C07F9/4015

    摘要： The invention relates to a novel important lycopene intermediate 3, 7, 11-trimethyl-1, 3, 6, 10-tetraene-dodecyl diethyl phosphonate. A current lycopene intermediate 2, 4, 6, 10-tetra-double bond pentadec-carbon phosphonate is difficult to synthesize. The invention provides a novel intermediate, which has the following synthesis steps of: preparing 2, 6, 10-trimethyl-3, 5, 9-undecane triene-1-aldehyde from pseudoionone; preparing 2, 6, 10-trimethyl-2, 5, 9-undecane triene-1-aldehyde from the 2, 6, 10-trimethyl-3, 5, 9-undecane triene-1-aldehyde; and subjecting the 2, 6, 10-trimethyl-2, 5, 9-undecane triene-1-aldehyde and tetraethyl methylenediphosphonate to condensation reaction to obtain target product. The invention can generate novel intermediate from raw material pseudoionone only by four reactions, thus the reactions are easy to control and great industrial value are achieved.

    摘要翻译： 本发明涉及新的重要番茄红素中间体3,7,11-三甲基-1,3,6,10-四烯十二烷基二乙基膦酸酯。 目前的番茄红素中间体2,4,6,10-四双键十五碳膦酸盐难以合成。 本发明提供了一种新型中间体，其具有以下合成步骤：由假性紫罗酮制备2,6,10-三甲基-3,5,9-十一烷三烯-1-醛; 由2,6,10-三甲基-3,5,9-十一烷三烯-1-醛制备2,6,10-三甲基-2,5,9-十一烷三烯-1-醛; 并使2,6,10-三甲基-2,5,9-十一烷三烯-1-醛和亚甲基二膦酸四乙酯发生缩合反应，得到目标产物。 本发明只需4个反应即可由原料假性紫罗酮生成新型中间体，反应易控制，具有很大的工业价值。