发明公开
- 专利标题： PROCEDE DE PREPARATION DE DERIVES DE 3-CETO-BENZOFURANE
- 专利标题（英）： Method for preparing 3-keto-benzofurane derivatives
- 专利标题（中）： 用于生产3-酮 - 苯并呋喃
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申请号： EP11719314.4申请日： 2011-03-30
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公开(公告)号： EP2552898A1公开(公告)日： 2013-02-06
- 发明人: BAILLY, Frédéric , PRIEM, Thomas , VAYRON, Philippe
- 申请人： SANOFI
- 申请人地址： 54, rue de la Boétie 75008 Paris FR
- 专利权人： SANOFI
- 当前专利权人： SANOFI
- 当前专利权人地址： 54, rue de la Boétie 75008 Paris FR
- 代理机构： Jacobson, Claude
- 优先权： FR1052332 20100330
- 国际公布： WO2011131881 20111027
- 主分类号： C07D307/79
- IPC分类号： C07D307/79 ; C07B45/04
摘要：
The invention relates to a method for preparing 3-keto-benzofurane derivatives of the general formula: Formula (I), where R is an alkyl or aryl group, R
1 is hydrogen or an alkyl or aryl group, and R
2 is a substituted alkyl or phenyl group. Said preparation method involves coupling a derivative of Formula III, where X is chlorine, bromine, or iodine or a sulfonate grouping: Formula (III) with a sulfonamide derivative of the formula R-SO
2 -NH
2 in the presence of a basic agent and a catalytic system formed of a complex between a palladium compound and a ligand.
1 is hydrogen or an alkyl or aryl group, and R
2 is a substituted alkyl or phenyl group. Said preparation method involves coupling a derivative of Formula III, where X is chlorine, bromine, or iodine or a sulfonate grouping: Formula (III) with a sulfonamide derivative of the formula R-SO
2 -NH
2 in the presence of a basic agent and a catalytic system formed of a complex between a palladium compound and a ligand.
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