公开(公告)号：EP1773783B1

公开(公告)日：2010-05-05

申请号：EP05790868.3

申请日：2005-07-20

申请人： Sanofi-Aventis

发明人： DAUMAS, Marc ,  DLUBALA, Alain ,  SOLE, Raphaël ,  VAYRON, Philippe

IPC分类号： C07D231/14

CPC分类号： C07D231/14

摘要： The invention concerns a method for preparing a compound of formula (I) wherein: R1 represents a hydrogen or halogen atom or a C1-C4 alkyl group; R2, R3, R4, R5, R6, R7 represent each independently of one another a hydrogen or halogen atom or a C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl group; as well as their salts.

公开(公告)号：EP1773783A1

公开(公告)日：2007-04-18

申请号：EP05790868.3

申请日：2005-07-20

申请人： Sanofi-Aventis

发明人： DAUMAS, Marc ,  DLUBALA, Alain ,  SOLE, Raphaël ,  VAYRON, Philippe

IPC分类号： C07D231/14

CPC分类号： C07D231/14

摘要： The invention concerns a method for preparing a compound of formula (I) wherein: R1 represents a hydrogen or halogen atom or a C1-C4 alkyl group; R2, R3, R4, R5, R6, R7 represent each independently of one another a hydrogen or halogen atom or a C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl group; as well as their salts.

公开(公告)号：EP2580224A1

公开(公告)日：2013-04-17

申请号：EP11729738.2

申请日：2011-06-10

申请人： SANOFI

发明人： FEREY, Vincent ,  MATEOS-CARO, Julia ,  MONDIERE, Régis ,  VAYRON, Philippe ,  VIGNE, Sylvie

IPC分类号： C07F17/02

CPC分类号： C07F17/02

摘要： The invention relates to a method of synthesis of ferroquine of formula (F) or of its metabolite of formula (Fm): comprising a reaction of reductive amination, said reaction comprising: (i) a stage of condensation of the aldhehyde-amino ferrocene of formula (1 ), which R represents a hydrogen atom or a methyl group, with the 7-chloroquinolin- amine of formula (2) as shown below, followed by (ii) a stage of reduction of the product of condensation obtained in the preceding stage (iii) then a stage of hydrolysis of the reaction mixture in the presence of an aqueous solution of ammonia or of citric acid.

公开(公告)号：EP2552898A1

公开(公告)日：2013-02-06

申请号：EP11719314.4

申请日：2011-03-30

申请人： SANOFI

发明人： BAILLY, Frédéric ,  PRIEM, Thomas ,  VAYRON, Philippe

IPC分类号： C07D307/79 ,  C07B45/04

CPC分类号： C07D307/81 ,  C07D307/79 ,  C07D307/80

摘要： The invention relates to a method for preparing 3-keto-benzofurane derivatives of the general formula: Formula (I), where R is an alkyl or aryl group, R
1 is hydrogen or an alkyl or aryl group, and R
2 is a substituted alkyl or phenyl group. Said preparation method involves coupling a derivative of Formula III, where X is chlorine, bromine, or iodine or a sulfonate grouping: Formula (III) with a sulfonamide derivative of the formula R-SO
2 -NH
2 in the presence of a basic agent and a catalytic system formed of a complex between a palladium compound and a ligand.

公开(公告)号：EP2542544A1

公开(公告)日：2013-01-09

申请号：EP11712941.1

申请日：2011-03-01

申请人： SANOFI

发明人： BAILLY, Frédéric ,  GRIMAUD, Bernard ,  MALEJONOCK, Irina ,  VAYRON, Philippe

IPC分类号： C07D307/83 ,  C07C217/22 ,  C07C225/16 ,  C07C311/07 ,  C07C311/08 ,  A61K31/43 ,  A61P9/00 ,  C07F5/02

CPC分类号： C07D307/83 ,  C07C217/22 ,  C07C225/16

摘要： The present invention relates to ketobenzofuran derivatives of the general formula (D) shown below, as well as to a method for synthesising same by coupling a quinonimine and an enaminone by a Nenitzescu reaction and to the intermediates of the synthesis thereof.

公开(公告)号：EP1753726B1

公开(公告)日：2010-01-06

申请号：EP05770985.9

申请日：2005-05-10

申请人： Sanofi-Aventis

发明人： DAUMAS, Marc ,  VAYRON, Philippe

IPC分类号： C07D231/16 ,  C07D231/22 ,  C07D231/14

CPC分类号： C07D231/24 ,  C07D231/14

公开(公告)号：EP1753726A1

公开(公告)日：2007-02-21

申请号：EP05770985.9

申请日：2005-05-10

申请人： Sanofi-Aventis

发明人： DAUMAS, Marc ,  VAYRON, Philippe

IPC分类号： C07D231/16 ,  C07D231/22 ,  C07D231/14

CPC分类号： C07D231/24 ,  C07D231/14

摘要： The invention relates a method for producing a compound of formula (I), wherein W is a -COOR group or CN radical, R1 is a hydrogen or halogen atom or a (Cl -C4)alkyl group, R3, R4, R5, R6, R7 represent independently of each other a hydrogen or halogen atom or a (Cl -C4)alkyl, (C1-C4)alkoxy or trifluoromethyl group and R is a (C1-C4)alkyl or benzyl group.

摘要翻译： 本发明涉及式（I）化合物的制备方法，其中W为-COOR基团或CN基团，R 1为氢或卤素原子或（C 1 -C 4）烷基，R 3，R 4，R 5，R 6 R7彼此独立地代表氢或卤素原子或（C1-C4）烷基，（C1-C4）烷氧基或三氟甲基，R是（C1-C4）烷基或苄基。

公开(公告)号：EP2580224B1

公开(公告)日：2014-05-28

申请号：EP11729738.2

申请日：2011-06-10

申请人： SANOFI

发明人： FEREY, Vincent ,  MATEOS-CARO, Julia ,  MONDIERE, Régis ,  VAYRON, Philippe ,  VIGNE, Sylvie

IPC分类号： C07F17/02

CPC分类号： C07F17/02

公开(公告)号：EP2595977A1

公开(公告)日：2013-05-29

申请号：EP11754896.6

申请日：2011-07-20

申请人： SANOFI

发明人： BAILLY, Fréderic ,  BON, Xavier ,  VAYRON, Philippe

IPC分类号： C07D307/80 ,  C07C251/16 ,  C07C39/04 ,  A61K31/343 ,  A61P9/00

CPC分类号： C07D307/80 ,  C07C49/76 ,  C07C251/60

摘要： The invention relates to a process for preparing benzofuran derivatives of general formula I, in which R represents a nitro or ester-COOR' group, where R' represents an alkyl group, R
1 represents hydrogen or an alkyl group and R
2 represents hydrogen, a halogen, a hydroxyl, haloalkyl, alkyl, alkoxy, dialkylaminoalkoxy or dialkylaminoalkyl group: by coupling the hydroxylamine with a diketone of general formula III: in order to form an oxime that is then cyclized by heating in order to form the desired compound.

公开(公告)号：EP2595976A1

公开(公告)日：2013-05-29

申请号：EP11754698.6

申请日：2011-07-18

申请人： SANOFI

发明人： BON, Xavier ,  BIENCOURT, Christine ,  LEROY, Corinne ,  MATEOS-CARO, Julia ,  VAYRON, Philippe

IPC分类号： C07D307/80

CPC分类号： A61K31/343 ,  C07D307/80

摘要： The invention relates to a process for preparing 5-aminobenzoylbenzofuran derivatives of formula (I), in which R
1 represents hydrogen or an alkyl group and R
2 represents hydrogen, an alkyl, alkoxy or dialkylaminoalkoxy group, by reduction of a 5-nitrobenzofuran derivative of formula (II) using a hydrogen transfer agent, in the presence of palladium-on-charcoal as catalyst and in an ether or an ether mixture as solvent.

摘要翻译： 本发明涉及制备式（I）的5-氨基苯甲酰基苯并呋喃衍生物的方法，其中R 1表示氢或烷基，R 2表示氢，烷基，烷氧基或二烷基氨基烷氧基，通过还原5-硝基苯并呋喃衍生物 使用氢转移剂，在作为催化剂的钯 - 炭的存在下和作为溶剂的醚或醚混合物中进行。