发明公开
- 专利标题： IMIDAZO[1,2-a]PYRIDINE DERIVATIVE
- 专利标题（中）： 咪唑并[1,2-A-] PYRIDINDERIVAT
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申请号： EP11774973.9申请日： 2011-04-26
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公开(公告)号： EP2565194A1公开(公告)日： 2013-03-06
- 发明人: SAMIZU, Kiyohiro , MASUDA, Naoyuki , IIKUBO, Kazuhiko , KOGANEMARU, Yohei , KAWANO, Noriyuki , OHMORI, Junya , MITANI, Yasuyuki , NI, Keni
- 申请人： Astellas Pharma Inc.
- 申请人地址： 3-11, Nihonbashi-Honcho 2-chome Chuo-ku Tokyo 103-8411 JP
- 专利权人： Astellas Pharma Inc.
- 当前专利权人： Astellas Pharma Inc.
- 当前专利权人地址： 3-11, Nihonbashi-Honcho 2-chome Chuo-ku Tokyo 103-8411 JP
- 代理机构： HOFFMANN EITLE
- 优先权： JP2010101557 20100427
- 国际公布： WO2011136192 20111103
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; A61K31/438 ; A61K31/4545 ; A61P25/18 ; A61P25/24 ; A61P25/28 ; A61P43/00 ; C07D495/14 ; C07D519/00
摘要：
[Problem]
To provide a compound useful as medicine having PDE4B inhibitory activity, in particular, as an active ingredient of a composition for treating or preventing schizophrenia, Alzheimer's disease, dementia, depression and the like.
[Measures for Solution]
The present inventors examined compounds having PDE4B inhibitory activity and found that a tricyclic or tetracyclic imidazo[1,2-a]pyridine derivative or salts thereof had a superior PDE4B inhibitory activity, thereby completing the present invention. The imidazo[1,2-a]pyridine derivative can be used as an agent for treating or preventing schizophrenia, Alzheimer's disease, dementia, depression and the like.
To provide a compound useful as medicine having PDE4B inhibitory activity, in particular, as an active ingredient of a composition for treating or preventing schizophrenia, Alzheimer's disease, dementia, depression and the like.
[Measures for Solution]
The present inventors examined compounds having PDE4B inhibitory activity and found that a tricyclic or tetracyclic imidazo[1,2-a]pyridine derivative or salts thereof had a superior PDE4B inhibitory activity, thereby completing the present invention. The imidazo[1,2-a]pyridine derivative can be used as an agent for treating or preventing schizophrenia, Alzheimer's disease, dementia, depression and the like.
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