发明公开
EP2566953A2 METHODS FOR CONTROL OF FLUX IN METABOLIC PATHWAYS THROUGH ENZYME RELOCATION
审中-公开
VERFAHREN ZUR FLUSSSTEUERUNG BEI STOFFWECHSELWEGEN DRUCH ENZYMUMPOSITIONIERUNG
- 专利标题： METHODS FOR CONTROL OF FLUX IN METABOLIC PATHWAYS THROUGH ENZYME RELOCATION
- 专利标题（中）： VERFAHREN ZUR FLUSSSTEUERUNG BEI STOFFWECHSELWEGEN DRUCH ENZYMUMPOSITIONIERUNG
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申请号： EP11721398.3申请日： 2011-05-06
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公开(公告)号： EP2566953A2公开(公告)日： 2013-03-13
- 发明人: SWARTZ, James, R.
- 申请人： Greenlight Biosciences, Inc. , The Board of Trustees of the Leland Stanford Junior University
- 申请人地址： 200 Boston Avenue Suite 4100 Medford, Massachusetts 02155-4257 US
- 专利权人： Greenlight Biosciences, Inc.,The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人： Greenlight Biosciences, Inc.,The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人地址： 200 Boston Avenue Suite 4100 Medford, Massachusetts 02155-4257 US
- 代理机构： Cornish, Kristina Victoria Joy
- 优先权： US332624P 20100507
- 国际公布： WO2011140516 20111110
- 主分类号： C12N1/00
- IPC分类号： C12N1/00 ; C12N1/06 ; C12N15/52
摘要：
Genetically manipulated cells, lysates of such cells, systems, and methods of use thereof are provided, where one or more enzymes in a pathway of interest are genetically modified to incorporate a peptide sequence that provides for relocation of the protein, e.g., to the periplasm, so as to sequester the enzyme, and where the enzyme controls flux in the pathway of interest.
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