发明公开
EP2582671A2 PROCESS FOR THE PREPARATION OF A SINGLE ENANTIOMER OF 3-AMINOPIPERIDINE DIHYDROCHLORIDE
审中-公开
方法用于生产单一对映体OFF 3-氨基二盐酸盐
- 专利标题： PROCESS FOR THE PREPARATION OF A SINGLE ENANTIOMER OF 3-AMINOPIPERIDINE DIHYDROCHLORIDE
- 专利标题（中）： 方法用于生产单一对映体OFF 3-氨基二盐酸盐
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申请号： EP11796521.0申请日： 2011-06-17
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公开(公告)号： EP2582671A2公开(公告)日： 2013-04-24
- 发明人: MEEK, Graham Andrew , KUNHIMON, Syam Kumar Unniaran Purakkal , SHANKAR, R. , DAHANUKAR, Vilas Hareshwar , MOHAN, TH. Krishna , WAGH, Manoj Balu , PAL, Abir Kumar , MEESALA, V. Madhu Babu , SHRIVASTAVA, Sonmit
- 申请人： Dr. Reddy's Laboratories Ltd. , Dr. Reddy's Laboratories Inc.
- 申请人地址： 8-2-337, Road No. 3 Banjara Hills Hyderabad 500 034 Andhra Pradesh IN
- 专利权人： Dr. Reddy's Laboratories Ltd.,Dr. Reddy's Laboratories Inc.
- 当前专利权人： Dr. Reddy's Laboratories Ltd.,Dr. Reddy's Laboratories Inc.
- 当前专利权人地址： 8-2-337, Road No. 3 Banjara Hills Hyderabad 500 034 Andhra Pradesh IN
- 代理机构： Müller-Boré & Partner Patentanwälte
- 优先权： US355692P 20100617
- 国际公布： WO2011160037 20111222
- 主分类号： C07D211/56
- IPC分类号： C07D211/56 ; B01J23/44 ; C07B55/00
摘要：
A process comprising: (a) reduction of N-acetyl-3-aminopyridine (2): or its salt in the presence of hydrogen and a palladium catalyst deposited on solid support; (b) converting racemic N-acetyl-3-aminopiperidine (3) or its salt produced in step (a) to rac-3-aminopiperidine (rac-4) or its salt; (c) resolution of the racemic 3-aminopiperidine (rac-4) or its salt produced in step (b) with a chiral acid.
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