发明公开
EP2585826A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
审中-公开
肾损伤和肾功能衰竭的诊断和预后的方法和组合物
- 专利标题： METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
- 专利标题（中）： 肾损伤和肾功能衰竭的诊断和预后的方法和组合物
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申请号： EP11798515.0申请日： 2011-06-23
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公开(公告)号： EP2585826A1公开(公告)日： 2013-05-01
- 发明人: ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
- 申请人： Astute Medical, Inc.
- 申请人地址： Blg 2 R. 645 3550 General Atomics Court San Diego, CA 92121 US
- 专利权人： Astute Medical, Inc.
- 当前专利权人： Astute Medical, Inc.
- 当前专利权人地址： Blg 2 R. 645 3550 General Atomics Court San Diego, CA 92121 US
- 代理机构： Schiweck, Weinzierl & Koch
- 优先权： US364300P 20100714; US357965P 20100623; US364304P 20100714; US357956P 20100623
- 国际公布： WO2011162820 20111229
- 主分类号： G01N33/48
- IPC分类号： G01N33/48 ; G01N33/53
摘要：
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of C-C Motif chemokine 24, and optinally Cancer antigen CA 15-3, C-C Motif chemokine 18, , Cathepsin D, C-X-C Motif chemokine 13, C-C motif chemokine 8, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, Interleukin-11, Matrix Metalloproteinase-8, Transforming growth factor alpha, IgG1, and IgG2 as diagnostic and prognostic biomarkers in renal injuries.
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