公开(公告)号：EP3734280B1

公开(公告)日：2022-06-01

申请号：EP20162229.7

申请日：2014-01-16

发明人： Anderberg, Joseph ,  Gray, Jeff ,  McPherson, Paul ,  Nakamura, Kevin ,  Kampf, James Patrick

IPC分类号： G01N33/566 ,  C12M1/34 ,  C40B30/04 ,  C40B60/12 ,  G01N33/573 ,  G01N33/68

公开(公告)号：EP3311164B1

公开(公告)日：2022-04-20

申请号：EP16812578.9

申请日：2016-06-17

发明人： McPHERSON, Paul ,  KAMPF, James Patrick ,  KWAN, Thomas ,  BACHUR, Richard ,  STEEN, Hanno

IPC分类号： G01N33/573 ,  G01N33/53

公开(公告)号：EP3153863B1

公开(公告)日：2020-04-01

申请号：EP16196505.8

申请日：2010-11-05

申请人： Astute Medical, Inc.

发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James Patrick

IPC分类号： G01N33/68

公开(公告)号：EP3361255B1

公开(公告)日：2020-03-11

申请号：EP18157605.9

申请日：2014-01-16

申请人： Astute Medical, Inc.

发明人： Anderberg, Joseph ,  Gray, Jeff ,  McPherson, Paul ,  Nakamura, Kevin ,  Kampf, James Patrick

IPC分类号： G01N33/566 ,  C12M1/34 ,  C40B30/04 ,  C40B60/12 ,  G01N33/573

公开(公告)号：EP3606554A1

公开(公告)日：2020-02-12

申请号：EP18781904.0

申请日：2018-04-04

申请人： Astute Medical, Inc.

发明人： VIJAYENDRAN, Ravi A. ,  VENKATASUBBARAO, Srivatsa

IPC分类号： A61K39/395 ,  C07K16/40 ,  C07K16/46 ,  C12N9/64 ,  C12N15/13 ,  C12P21/08

公开(公告)号：EP3532101A1

公开(公告)日：2019-09-04

申请号：EP17865610.4

申请日：2017-10-27

申请人： Astute Medical, Inc. ,  University of Pittsburgh- Of the Commonwealth System of Higher Education

发明人： McPHERSON, Paul ,  KELLUM, John, A.

IPC分类号： A61K39/395 ,  A61K39/00 ,  A61K38/00 ,  G01N33/00 ,  C12M3/00

公开(公告)号：EP2899545B1

公开(公告)日：2018-08-22

申请号：EP15151607.7

申请日：2011-06-23

申请人： Astute Medical, Inc.

发明人： Anderberg, Joseph ,  Gray, Jeff ,  McPherson, Paul ,  Nakamura, Kevin ,  Kampf, James Patrick

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/6854 ,  G01N33/6863 ,  G01N33/74 ,  G01N2333/4725 ,  G01N2333/4745 ,  G01N2333/495 ,  G01N2333/521 ,  G01N2333/5431 ,  G01N2333/7155 ,  G01N2333/96472 ,  G01N2333/96494 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/56

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of C-C Motif chemokine 24, and optinally Cancer antigen CA 15-3, C-C Motif chemokine 18, , Cathepsin D, C-X-C Motif chemokine 13, C-C motif chemokine 8, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, Interleukin-11, Matrix Metalloproteinase-8, Transforming growth factor alpha, IgG1, and IgG2 as diagnostic and prognostic biomarkers in renal injuries.

公开(公告)号：EP3210018A4

公开(公告)日：2018-06-20

申请号：EP15853584

申请日：2015-10-20

申请人： ASTUTE MEDICAL INC

发明人： ANDERBERG JOSEPH ,  MCPHERSON PAUL ,  GRAY JEFF ,  NAKAMURA KEVIN ,  KAMPF JAMES PATRICK ,  KWAN THOMAS

IPC分类号： G01N33/50

CPC分类号： G01N33/6872 ,  G01N33/6863 ,  G01N33/6893 ,  G01N2333/521 ,  G01N2333/71 ,  G01N2800/347

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of C-C motif chemokine 16, C-C motif chemokine 14, and Tyrosine-protein kinase receptor UFO as diagnostic and prognostic biomarker assays in renal injuries.

公开(公告)号：EP3308166A1

公开(公告)日：2018-04-18

申请号：EP16808459.8

申请日：2016-06-10

申请人： Astute Medical, Inc.

发明人： ANDERBERG, Joseph ,  McPHERSON, Paul ,  GRAY, Jeff ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick ,  KWAN, Thomas

IPC分类号： G01N33/53

CPC分类号： G01N33/6893 ,  G01N2333/4703 ,  G01N2333/70596 ,  G01N2333/96466 ,  G01N2800/347 ,  G01N2800/348

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of Follistatin-related protein 3, Basigin, Cathepsin B, and Tenascin as diagnostic and prognostic bio-marker assays in renal injuries.

公开(公告)号：EP3273246A1

公开(公告)日：2018-01-24

申请号：EP17185251.0

申请日：2009-08-28

申请人： Astute Medical, Inc.

发明人： Anderberg, Joseph ,  Gray, Jeff ,  McPherson, Paul ,  Nakamura, Kevin

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2800/347

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect leukocyte elastase, and optionally further one or more markers of soluble p-selectin, protein NOV homolog, soluble epidermal growth factor receptor, netrin-4, haptoglobin, heat shock protein beta-1, alpha-1-antitrypsin, soluble tumor necrosis factor receptor superfamily member 6, soluble tumor necrosis factor ligand superfamily member 6, soluble intercellular adhesion molecule 2, active caspase-3, and soluble platelet endothelial cell adhesion molecule as diagnostic and prognostic biomarkers in renal injuries.

摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 具体而言，本发明涉及使用检测白细胞弹性蛋白酶的分析以及可选的可溶性p-选择蛋白，蛋白NOV同系物，可溶性表皮生长因子受体，netrin-4，触珠蛋白，热休克蛋白β-1， α-1-抗胰蛋白酶，可溶性肿瘤坏死因子受体超家族成员6，可溶性肿瘤坏死因子配体超家族成员6，可溶性细胞间粘附分子2，活性胱天蛋白酶-3和可溶性血小板内皮细胞粘附分子作为肾损伤中的诊断和预后生物标志物 。