发明公开
- 专利标题： RHO KINASE INHIBITORS
- 专利标题（中）： Rho激酶抑制剂
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申请号： EP11730533.4申请日： 2011-06-30
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公开(公告)号： EP2590942A1公开(公告)日： 2013-05-15
- 发明人: GINN, John David , MARSHALL, Daniel Richard , SIBLEY, Robert , SORCEK, Ronald John , YOUNG, Erick Richard Roush , ZHANG, Yunlong
- 申请人： Boehringer Ingelheim International GmbH
- 申请人地址： Binger Strasse 173 55216 Ingelheim am Rhein DE
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： Binger Strasse 173 55216 Ingelheim am Rhein DE
- 代理机构： Simon, Elke Anna Maria
- 优先权： US362036P 20100707
- 国际公布： WO2012006202 20120112
- 主分类号： C07D207/09
- IPC分类号： C07D207/09 ; C07D217/22 ; C07D277/60 ; C07D401/12 ; C07D417/12 ; C07D417/14 ; C07D513/04 ; A61P9/00 ; A61P25/00 ; A61K31/437 ; A61K31/5377 ; A61K31/426 ; A61K31/40
摘要：
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R
1 and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of Rho Kinase-mediated disorders selected from hypertension, atherosclerosis, restenosis, stroke, myocardial infarction, heart failure, coronary artery disease, peripheral artery disease, coronary vasospasm, cerebral vasospasm, ischemia/reperfusion injury, pulmonary hypertension, angina, erectile dysfunction, renal disease, organ failure, asthma, glaucoma, cancer, Alzheimer's disease, multiple sclerosis, spinal cord injury, neuropathic pain, rheumatoid arthritis, psoriasis inflammatory bowel disease, and combinations of such disorders.
1 and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of Rho Kinase-mediated disorders selected from hypertension, atherosclerosis, restenosis, stroke, myocardial infarction, heart failure, coronary artery disease, peripheral artery disease, coronary vasospasm, cerebral vasospasm, ischemia/reperfusion injury, pulmonary hypertension, angina, erectile dysfunction, renal disease, organ failure, asthma, glaucoma, cancer, Alzheimer's disease, multiple sclerosis, spinal cord injury, neuropathic pain, rheumatoid arthritis, psoriasis inflammatory bowel disease, and combinations of such disorders.
公开/授权文献
- EP2590942B1 RHO KINASE INHIBITORS 公开/授权日：2016-05-04
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